Method for the simultaneous and direct determination of serum cholesterol in high an low density lipoproteins using infrared spectroscopy
First Claim
Patent Images
1. A method of determining the concentration of at least one cardiovascular risk marker selected from the group consisting of High Density Lipoprotein cholesterol (HDL-C), Low Density Lipoprotein cholesterol (LDL-C), and oxidized LDL comprising:
- subjecting a serum sample to infra-red light;
collecting at least one spectrum of infrared light after interaction with the sample; and
determining the concentration of the cardiovascular risk marker in the sample based on the intensity of spectral features or patterns over at least one spectral range selected from the group consisting of 900-1,500 cm−
1, 1500-1800 cm−
1, and 2800-3500 cm−
1.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of simultaneously determining the concentrations of cardiovascular risk markers selected from the group consisting of High Density Lipoprotein cholesterol (HDL-C), Low Density Lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides and oxidized LDL using infra-red and/or near infrared light is described
-
Citations
13 Claims
-
1. A method of determining the concentration of at least one cardiovascular risk marker selected from the group consisting of High Density Lipoprotein cholesterol (HDL-C), Low Density Lipoprotein cholesterol (LDL-C), and oxidized LDL comprising:
-
subjecting a serum sample to infra-red light;
collecting at least one spectrum of infrared light after interaction with the sample; and
determining the concentration of the cardiovascular risk marker in the sample based on the intensity of spectral features or patterns over at least one spectral range selected from the group consisting of 900-1,500 cm−
1, 1500-1800 cm−
1, and 2800-3500 cm−
1. - View Dependent Claims (2, 3, 4)
-
-
5. A method of determining the concentration of High Density Lipoprotein cholesterol (HDL-C) comprising:
-
subjecting a serum sample to infra-red light;
collecting at least one spectrum of infrared light after interaction with the sample; and
determining the concentration of HDL-C in the sample based on the intensity of spectral features or patterns over at least one spectral range selected from the group consisting of 900-1500 cm−
1, 1500-1800 cm−
1, and 2800-3500 cm−
1. - View Dependent Claims (6, 7)
-
-
8. A method of determining the concentration of Low Density Lipoprotein cholesterol (LDL-C) comprising:
-
subjecting a serum sample to infra-red light;
collecting at least one spectrum of infrared light after interaction with the sample;
determining the concentration of LDL-C in the sample based upon the intensity of spectral features or patterns over at least one spectral range selected from the group consisting of 1700-1800 cm−
1, and 2800-3000 cm−
1. - View Dependent Claims (9, 10)
-
-
11. A method of determining the concentration of oxidized LDL comprising:
-
subjecting a serum sample to infra-red light;
collecting at least one spectrum of infrared light after interaction with the sample;
quantifying the species of interest based upon the intensity of spectral features or patterns over at least one spectral range selected from the group consisting of 1500-1800 cm−
1, and 2800-3500 cm−
1. - View Dependent Claims (12, 13)
-
Specification