Methods and compounds for inhibiting amyloid deposits
First Claim
1. A method for inhibiting IAPP-associated amyloid deposits in a subject, comprising administering to said subject an effective amount of an IAPP-inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that said IAPP-associated amyloid deposits are inhibited.
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Accused Products
Abstract
Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.
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Citations
21 Claims
- 1. A method for inhibiting IAPP-associated amyloid deposits in a subject, comprising administering to said subject an effective amount of an IAPP-inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that said IAPP-associated amyloid deposits are inhibited.
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7. A method for inhibiting IAPP fibrillogenesis in a subject, comprising administering to said subject an effective amount of an IAPP inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that IAPP fibrillogenesis is inhibited.
- 8. A pharmaceutical composition for inhibiting IAPP-associated amyloid deposits, comprising an amyloid-inhibiting amount of a therapeutic compound of the formula
- 10. A pharmaceutical composition for inhibiting IAPP-associated amyloid deposits, comprising an amyloid-inhibiting amount of a therapeutic compound of the formula
- 12. A method for reducing IAPP-associated amyloid deposits in a subject having IAPP-associated amyloid deposits, the method comprising administering to said subject an effective amount of an IAPP inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that said IAPP-associated amyloid deposits are inhibited.
- 18. A method for inhibiting amyloid deposits in a subject, comprising administering to said subject an effective amount of a compound of the formula
- 20. A method for inhibiting amyloid deposits in a subject, comprising administering to said subject an effective amount of a compound of the formula
Specification