Potentiated topical composition

• US 20040248993A1
• Filed: 08/09/2004
• Published: 12/09/2004
• Est. Priority Date: 10/21/2001
• Status: Active Grant

• Current Assignee: Ambria Dermatology AB (Nimutan AB)
• Original Assignee: Ambria Dermatology AB (Nimutan AB)
• Inventors: Hedner, Thomas, Faergemann, Jan
• Granted Patent: US 8,642,053 B2
• Time in Patent Office: Days
• US Class Current: 514/738
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 1/06 Lipsticks
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin

Abstract

A topical composition for skin care or administration of a pharmacologically active agent in form of a lotion, cream or similar comprises from 5% to 70% by weight of pentane-1,5-diol and a cosmetically or pharmaceutically acceptable carrier, with the proviso that the composition does not comprise polysiloxane, volatile siloxane, phosphatidyl-choline, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, monoglyceride of myristic acid. Also disclosed are corresponding methods of administration, a patch for holding said composition against the skin, and methods of preventing or treating a dry skin condition and of keeping skin in a humid state.

Claims

1. A topical composition for skin care or administration of a pharmacologically active agent comprising from 5% by weight to 70% by weight of pentane-1,5-diol and a cosmetically or pharmaceutically acceptable carrier,

with the proviso that the composition does not comprise polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, or monoglyceride of myristic acid.

2. The composition of claim 1, comprising from 15% by weight to 40% by weight of pentane-1,5-diol.

3. The composition of claim 1, comprising from 20-35% of pentane-1,5-diol.

4. The composition of claim 1 wherein the cosmetically or pharmaceutically acceptable carrier comprises less than 20% by weight of propane-1,2-diol, glycerol or a combination thereof.

5. The composition of claim 4, comprising less than 5% by weight of propane-1,2-diol, glycerol or a combination thereof.

7. The composition of claim 1, comprising from 0.1 to 30% by weight of water.

8. The composition of claim 1, comprising a tonicity adjusting agent.

11. The composition of claim 1, comprising a UV-absorbing agent.

12. The composition of claim 1, comprising a colorant selected from the group consisting of titanium dioxide, calcium carbonate and zinc oxide.

13. The composition of claim 1, comprising a fragrant agent.

14. The composition of claim 1, comprising an anionic emulsifying wax.

15. The composition of claim 1, in the form of a cream, a liquid, a lotion, an ointment, a paste, a gel, a shampoo, a spray, or a lipstick.

16. A patch impregnated with the composition of claim 1.

17. The pharmaceutical composition of claim 1, wherein the pharmacologically active agent is selected from the group consisting of steroids, antimycotic agents, agents for treating diseases of the thyroidea, antibiotics, antiviral agents, antihistamines antiseptics, agents for the treatment of acne, agents for the treatment of warts, NSAIDs, COX2 selective agents, local anesthetics, agents for the treatment of psoriasis and eczema, cytostatics, polypeptides, and TNF-α

blockers.

18. The pharmaceutical composition of claim 1, comprising salicylic acid.

20. A sealed container filled with the composition of claim 1.

31. The composition of claim 1, comprising from 20-35% of pentane-1,5-diol and less than 5% by weight of propane-1,2-diol, glycerol or a combination thereof.

32. The composition of claim 4, comprising from 0.1 to 30% by weight of water.

6. The composition of 5, wherein the cosmetically or pharmaceutically acceptable carrier comprises less than 1% by weight of propane-1,2-diol, glycerol or a combination thereof.

19. A patch impregnated with the composition of claim 6 enclosed in a sealed plastic envelope.

9. The composition of, comprising from 0.1% by weight to 20% by weight of at least one or several of carbamide, NaCl, and lactic acid.

10. The composition of, comprising from 0.1 to 30% by weight of polyethylene glycol.

21. A method of topically administering a pharmaceutical agent, comprising forming a solution, emulsion, suspension, ointment or cream of a pharmacologically effective amount of said agent in a carrier comprising from 5% to 70% by weight of pentane-1,5-diol, followed by applying said solution emulsion, suspension, ointment or cream to a selected site of the skin of a person to be treated for a condition or disease against which said pharmaceutical agent is effective.

22. The method of claim 21, wherein administration comprises providing said solution, emulsion, suspension, ointment or cream on a patch or other suitable device for holding it against the selected skin site.

23. A method of treating or preventing a dry skin condition, including dermatitis, the method comprising:

providing a pharmaceutical composition in form of a solution, suspension, emulsion, cream or ointment, which comprises from 5% to 70% by weight of pentane-1,5-diol;

applying said solution, emulsion, suspension, ointment or cream to a selected site of the skin of a person to be treated.

24. The method of claim 23, wherein the application comprises providing said pharmaceutical composition on a patch or other suitable device capable of being applied to the selected site of the skin.

25. The method of claim 23, wherein the pharmaceutical composition does not comprise polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, or monoglyceride of myristic acid.

30. The method of claim 24, wherein the pharmaceutical composition does not comprise polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, or monoglyceride of myristic acid.

26. A method of preserving the skin of a person in a humid state, the method comprising (i) providing a cosmetic composition in form of a solution, emulsion, suspension, ointment or cream, which comprises from 5% to 70% by weight of pentane-1,5-diol, and (ii) applying the solution, emulsion, suspension, ointment or cream to the skin to be preserved in a humid state.

27. The method of claim 26, with the proviso that the cosmetic composition does not comprise polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, or monoglyceride of myristic acid.

28-29. -29. (canceled).