Perivascular leak repair system

• US 20040249413A1
• Filed: 04/29/2004
• Published: 12/09/2004
• Est. Priority Date: 04/30/2003
• Status: Active Grant

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Inventors: Coppin, Chris M., Allen, Jeffrey W., Brin, David S.
• Granted Patent: US 7,577,477 B2
• Time in Patent Office: Days
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00783 Valvuloplasty
• CPC Class Codes: A61F 2/2409 Support rings therefor, e.g. for connecting valves to tissue annuloplasty rings A61F2/2442

Abstract

The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir with a repair catheter operably attached; a flow control device disposed between the sealant reservoir and the repair catheter, and the flow control device responsive to a flow control signal; a heart phase detector generating a diastole phase signal; an injection switch generating a injection signal; and a flow controller responsive to the diastole phase signal and the injection signal, and generating the flow control signal. A method of sealing a perivascular leak comprises identifying the perivascular leak; inserting a repair catheter to the perivascular leak; injecting sealant at the perivascular leak; and removing the repair catheter. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.

Claims

1. A perivascular leak repair system comprising:

a sealant reservoir;

a repair catheter, the repair catheter being operably attached to the sealant reservoir;

a flow control device, the flow control device being disposed between the sealant reservoir and the repair catheter, and being responsive to a flow control signal;

a heart phase detector, the heart phase detector generating a diastole phase signal;

an injection switch, the injection switch generating a injection signal; and

a flow controller, the flow controller being responsive to the diastole phase signal and the injection signal, and generating the flow control signal.

2. The system of claim 1 further comprising a injection amount selector, the injection amount selector generating a injection amount signal, wherein the flow controller is responsive to the injection amount signal.

3. The system of claim 1 wherein the heart phase detector monitors heartbeat using input from a device selected from the group consisting of a pressure sensor disposed on the repair catheter, a Doppler echo probe disposed on the repair catheter, and an electrocardiogram.

4. The system of claim 1 wherein the sealant reservoir is pressurized and the flow control device is a valve.

5. The system of claim 1 wherein the flow control device is a pump.

6. The system of claim 1 wherein the repair catheter is steerable.

7. The system of claim 1 further comprising a filter disposed on the repair catheter.

8. The system of claim 1 further comprising a pressure sensor disposed on the repair catheter.

9. The system of claim 1 further comprising a Doppler echo probe disposed on the repair catheter.

10. The system of claim 1 further comprising an emboli detector.

15. The method of claim 11 wherein injecting sealant at the perivascular leak comprises monitoring heart phase for diastole and injecting sealant at the perivascular leak during the diastole.

16. The method of claim 15 further comprising injecting sealant at the perivascular leak only during the diastole.

11. A method of sealing a perivascular leak comprising:

identifying the perivascular leak;

inserting a repair catheter to the perivascular leak;

injecting sealant at the perivascular leak; and

removing the repair catheter.

12. The method of claim 11 wherein the sealant is selected from the group consisting of fibrin glue, collagen paste, activated platelet gel, hydrogels, N-butyl cyanoacrylate, isobutyl-2cyanoacrylate, alykyl cyanoacrylate, silicone rubber, Ethibloc amino acid gel, autologous material, fat dura, EVAL ethylene vinyl alcohol copolymer, EMBOLYX ethylene vinyl alcohol copolymer, poly-vinyl alcohol, alginates, polysachrides, posphoryl choline-hydrogel, activated microparticles, and combinations thereof.

13. The method of claim 11 wherein identifying the perivascular leak comprises identifying the perivascular leak by echocardiography.

14. The method of claim 11 further comprising locating the repair catheter with a system selected from the group of an imaging system, a navigation system, a fluoroscopy system, and a non-fluoroscopic intracardiac navigation system.

17. The method of claim 11 wherein injecting sealant at the perivascular leak comprises injecting sealant at the perivascular leak in a predetermined amount.

18. The method of claim 11 further comprising:

checking whether the perivascular leak is sealed; and

injecting sealant at the perivascular leak if the perivascular leak is not sealed.

19. The method of claim 11 wherein inserting a repair catheter to the perivascular leak comprises inserting a repair catheter into the ascending aorta.

20. The method of claim 19 wherein inserting a repair catheter into the ascending aorta comprises inserting a repair catheter into the ascending aorta by a route selected from the group consisting of through the groin percutaneously and through the aortic wall.

21. The method of claim 11 wherein the repair catheter has a distal tip and further comprising inserting a filter proximal the distal tip.

22. A system for sealing a perivascular leak comprising:

means for identifying the perivascular leak;

means for inserting a repair catheter to the perivascular leak;

means for injecting sealant at the perivascular leak; and

means for removing the repair catheter.

23. The system of claim 22 wherein the sealant is selected from the group consisting of fibrin glue, collagen paste, activated platelet gel, hydrogels, N-butyl cyanoacrylate, isobutyl-2 cyanoacrylate, alykyl cyanoacrylate, silicone rubber, Ethibloc amino acid gel, autologous material, fat dura, EVAL ethylene vinyl alcohol copolymer, EMBOLYX ethylene vinyl alcohol copolymer, poly-vinyl alcohol, alginates, polysachrides, posphoryl choline-hydrogel, activated microparticles, and combinations thereof.

24. The system of claim 22 wherein the means for identifying the perivascular leak is echocardiography.

25. The system of claim 22 further comprising means for locating the repair catheter.

26. The system of claim 22 wherein means for injecting sealant at the perivascular leak comprises means for monitoring heart phase for diastole and means for injecting sealant at the perivascular leak during the diastole.

27. The system of claim 26 further comprising means for injecting sealant at the perivascular leak only during the diastole.

28. The system of claim 22 wherein the means for injecting sealant at the perivascular leak comprises means for injecting sealant at the perivascular leak in a predetermined amount.

29. The system of claim 22 further comprising:

means for checking whether the perivascular leak is sealed; and

means for injecting sealant at the perivascular leak if the perivascular leak is not sealed.

30. A perivascular leak repair system comprising:

a syringe;

a repair catheter, the repair catheter being operably attached to the syringe;

a flow control valve, the flow control valve being disposed between the syringe and the repair catheter, and being responsive to a flow control signal;

a heart phase detector, the heart phase detector generating a diastole phase signal; and

a flow controller, the flow controller being responsive to the diastole phase signal and generating the flow control signal.

31. The system of claim 30 wherein the heart phase detector monitors heartbeat using input from a device selected from the group consisting of a pressure sensor disposed on the repair catheter, a Doppler echo probe disposed on the repair catheter, and an electrocardiogram.