Implantable or insertable medical device resistant to microbial growth and biofilm formation
First Claim
1. An implantable medical device comprising (a) at least one biocompatible matrix polymer region and (b) bioactive agents comprising an antimicrobial agent and a microbial attachment/biofilm synthesis inhibitor.
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Accused Products
Abstract
Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents
187 Citations
94 Claims
- 1. An implantable medical device comprising (a) at least one biocompatible matrix polymer region and (b) bioactive agents comprising an antimicrobial agent and a microbial attachment/biofilm synthesis inhibitor.
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48. A method of manufacturing an implantable or insertable medical device comprising:
- providing a combination of (a) one or more biocompatible matrix polymers and (b) bioactive agents comprising an antimicrobial agent and a microbial attachment/biofilm synthesis inhibitor;
processing said combination under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of any of said biocompatible matrix polymers and that substantially prevent chemical modification of said bioactive agents. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
- providing a combination of (a) one or more biocompatible matrix polymers and (b) bioactive agents comprising an antimicrobial agent and a microbial attachment/biofilm synthesis inhibitor;
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72. An implantable or insertable medical device comprising at least one biocompatible matrix polymer region comprising a material selected from the group consisting of ethylene vinyl acetate copolymers, copolymers of ethylene with acrylic acid or methacrylic acid, metallocene catalyzed polyethylenes and polyethylene copolymers, ionomers, vinyl aromatic copolymers, elastomeric polyurethanes and polyurethane copolymers, silicones and mixtures thereof;
- bioactive agents comprising an antimicrobial agent selected from the group consisting of triclosan, chlorhexidine and mixtures thereof;
a microbial attachment/biofilm synthesis inhibitor selected from the group consisting of salicylic acid and salts and derivatives thereof; and
, a radio-opacifying agent selected from the group consisting of bismuth subcarbonate, bismuth oxychloride, bismuth trioxide, barium sulfate, tungsten and mixtures thereof.
- bioactive agents comprising an antimicrobial agent selected from the group consisting of triclosan, chlorhexidine and mixtures thereof;
- 73. A stent comprising a polymeric tubular shaft, said polymeric tubular shaft comprising triclosan and a matrix polymer.
- 87. A ureteral stent comprising a polymeric tubular shaft that is between 0.2 mm and 0.8 mm in wall thickness, said polymeric tubular shaft comprising (a) polymeric species consisting essentially of ethylene vinyl acetate copolymer and (b) antimicrobial species consisting essentially of triclosan.
Specification