Use of a clostridial toxin to reduce appetite
First Claim
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1. A method for inhibiting secretion of Ghrelin by a stomach cell, the method comprising the step of administration of a botulinum toxin to a stomach cell capable of secreting Ghrelin, thereby inhibiting the secretion of Ghrelin from the stomach cell.
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Abstract
Methods for reducing appetite by oral administration of a Clostridial toxin, such as a botulinum toxin.
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20 Claims
- 1. A method for inhibiting secretion of Ghrelin by a stomach cell, the method comprising the step of administration of a botulinum toxin to a stomach cell capable of secreting Ghrelin, thereby inhibiting the secretion of Ghrelin from the stomach cell.
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6. A method for inhibiting secretion of Ghrelin by a stomach cell, the method comprising the step of oral ingestion of a botulinum toxin type A to a Ghrelin secreting stomach cell thereby inhibiting the secretion of Ghrelin from the stomach cell.
- 7. A method for inhibiting release of growth hormone from a pituitary cell, the method comprising the step of administration of a botulinum toxin to a stomach cell capable of secreting Ghrelin, thereby reducing the secretion of Ghrelin from the stomach cell and inhibiting release of growth hormone from a pituitary cell.
- 12. A method for reducing appetite, the method comprising the step of oral administration of a, botulinum toxin, thereby reducing appetite.
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17. A method for reducing appetite, the method comprising the step of oral administration of a botulinum toxin type A to a stomach cell capable of secreting Ghrelin, thereby inhibiting the secretion of Ghrelin from the stomach cell and reducing appetite.
- 18. A method for reducing appetite, the method comprising the step of oral administration of a botulinum toxin, wherein the botulinum toxin is orally administered in an amount sufficient to reduce secretion of Ghrelin by a stomach cell, but in an amount insufficient to cause symptoms of systemic toxicity to the botulinum toxin.
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