Markers for differential diagnosis and methods of use thereof
First Claim
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1. A method of analyzing a subject sample for a plurality of subject-derived markers selected to distinguish amongst a plurality of cardiovascular disorders, comprising:
- assaying said sample for the presence or amount of one or more subject-derived markers related to blood pressure regulation, and for the presence or amount of one or more subject-derived markers related to myocardial injury, and characterizing said subject'"'"'s risk of having developed or of developing each of said plurality of cardiovascular disorders based upon the presence or amount of said markers, wherein the amount of at least one of said one or more subject-derived markers is not compared to a predetermined threshold amount.
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Abstract
The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases. In various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease underlying one or more non-specific symptoms exhibited in a clinical setting.
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Citations
36 Claims
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1. A method of analyzing a subject sample for a plurality of subject-derived markers selected to distinguish amongst a plurality of cardiovascular disorders, comprising:
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assaying said sample for the presence or amount of one or more subject-derived markers related to blood pressure regulation, and for the presence or amount of one or more subject-derived markers related to myocardial injury, and characterizing said subject'"'"'s risk of having developed or of developing each of said plurality of cardiovascular disorders based upon the presence or amount of said markers, wherein the amount of at least one of said one or more subject-derived markers is not compared to a predetermined threshold amount. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of analyzing a subject sample for a plurality of subject-derived markers selected to distinguish amongst a plurality of cerebrovascular disorders, comprising:
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assaying said sample for the presence or amount of one or more subject-derived markers related to blood pressure regulation, and for the presence or amount of one or more subject-derived markers related to neural tissue injury, and characterizing said subject'"'"'s risk of having developed or of developing each of said plurality of cerebrovascular disorders based upon the presence or amount of said markers, wherein the amount of one or more of said markers is not compared to a predetermined threshold amount. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method of analyzing a subject sample for a plurality of subject-derived markers selected to identify subjects suffering from myocardial infarction, comprising:
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assaying said sample for the presence or amount of a plurality of subject-derived marker(s) related to myocardial injury selected from the group consisting of free cardiac troponin I, free cardiac troponin T, cardiac troponin I in a complex comprising one or both of troponin T and troponin C, cardiac troponin T in a complex comprising one or both of troponin I and troponin C, free and complexed cardiac troponin I, free and complexed cardiac troponin T, creatine kinase-MB, myoglobin, glycogen phosphorylase-BB, annexin B, β
-enolase, heart-type fatty acid binding protein, and S-100ao, andcharacterizing said subject'"'"'s risk of having suffered a myocardial infarction based upon the presence or amount of said markers, wherein the amount of each of said markers is not compared to a predetermined threshold amount.
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Specification