Test device

• US 20040253715A1
• Filed: 05/06/2004
• Published: 12/16/2004
• Est. Priority Date: 05/08/2003
• Status: Abandoned Application

• Current Assignee: Cedi Diagnostics B.V.
• Original Assignee: Cedi Diagnostics B.V.
• Inventors: Schielen, Wilhelmus Joseph G., Keizer, Gerrit Dirk
• Application Number:
  US10/842,969
• Publication Number:
  US 20040253715A1
• Time in Patent Office: Days
• US Class Current: 435/287.2
• CPC Class Codes: B01L 2200/16 Reagents, handling or storing thereof
• CPC Class Codes: B01L 2300/042 Caps; Plugs
• CPC Class Codes: B01L 2300/047 Additional chamber, reservoir
• CPC Class Codes: B01L 2300/0663 Whole sensors
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 3/50825 Closing or opening means, corks, bungs closures for containers B65D; means for removing stoppers B67B7/02
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing

Abstract

The invention is in the field of biomedical testing and relates to a device for detecting the presence of chemical and/or biological substances in a sample comprising a reagent compartment (1) which is contained in a cylindrical housing (2), which cylindrical housing (2) comprises at least a first open end; and a sample receiver (8) which is also contained in said cylindrical housing (2); and an operating means (4) capable of moving said reagent compartment (1) and/or said sample receiver (3); and wherein the reagent compartment (1) and the sample receiver (3) can be in at least two positions relative to each other, said positions comprising a first position wherein the sample receiver (3) is not in analyte-exchangeable contact with the reagent compartment (1), and a second position wherein the sample receiver (3) is in analyte-exchangeable contact with the reagent compartment (1).

Claims

1. Test device for determining an analyte in a sample, the device comprising:

a reagent compartment (1) which is contained in a cylindrical housing (2), which cylindrical housing (2) comprises at least a first open end; and

a sample receiver (3) which is also contained in said cylindrical housing (2); and

an operating means (4) capable of moving said reagent compartment (1) and/or said sample receiver (3);

and wherein the reagent compartment (1) and the sample receiver (3) can be in at least two positions relative to each other, said positions comprising a first position wherein the sample receiver (3) is not in analyte-exchangeable contact with the reagent compartment (1), and a second position wherein the sample receiver (3) is in analyte-exchangeable contact with the reagent compartment (1).

2. Test device according to claim 1, wherein the sample receiver (3) and the operating means are fixedly connected so as to form a sample taker (5).

3. Test device according to claim 2, wherein the sample taker (5) can be removed from the cylindrical housing.

4. Test device according to claim 1 or 2, wherein said cylindrical housing (2) comprises a second open end that can be closed by a removable lid (17), and wherein the sample receiver (3) is located between the reagent compartment (1) and the second open end.

5. Test device according to any one of the preceding claims, wherein said operating means (4) also comprises a closing means (7) for air-tight closure of said first open end.

6. Test device according to any one of the preceding claims, wherein said sample receiver (3) comprises absorbent materials, preferably said absorbent materials are mixed together and/or stacked in layers, said layers optionally being alternated or divided by one or more (semi)permeable membranes.

7. Test device according to claim 6, wherein the amount of absorbent materials provides defined sample volumes when soaked in sample fluid.

8. Test device according to any one of the preceding claims, wherein said sample receiver (3) comprises a probing element (15).

9. Test device according to according to any one of claims 4-8, wherein a sample uptake element (18) extends from said second open end.

10. Test device according to any one of the preceding claims, wherein said sample receiver (3) comprises reagents.

11. Ordered array of test devices, comprising a plurality of test devices according to any one of the preceding claims, wherein a plurality of cylindrical housings (2), each containing a reagent compartment (1), are interconnected to form an ordered array, and wherein an equal amount of sample takers (5) are interconnected to form a complementary array.

12. Array of test devices according to claim 11, wherein said interconnected plurality of cylindrical housings (2), each containing a reagent compartment (1), forms an array in a micro-well format.

15. Use of test devices according to any one of the claims 1-12, for determining an analyte in a sample.

16. Use according to claim 15, wherein the sample is milk, liquor, serum, plasma and/or whole blood.

17. Use according to claim 15 or 16, wherein the analyte is a nucleotide, a peptide and/or a saccharide, and/or a polymer thereof.

18. Use according to any one of the claims 15 to 17, wherein the analyte is an a toxin, a pesticide, a antibiotic, an antibody, an antigen, an enzyme, a cofactor, a hormone, a virus, a bacterium and/or a fungus.

13. Method for determining the presence of an analyte in a sample comprising:

a) providing a test device or determining an analyte in a sample, the device comprising;

a reagent compartment (1) which is contained in a cylindrical housing (2), which cylindrical housing (2) comprises at least a first open end; and

a sample receiver (3) which is also contained in said cylindrical housing (2); and

an operating means (4) capable of moving said reagent compartment (1) and/or said sample receiver (3); and

wherein the reagent compartment (1) and the sample receiver (3) can be in at least two positions relative to each other, said positions comprising a first position wherein the sample receiver (3) is not in analyte-exchangeable contact with the reagent compartment (1), and a second position wherein the sample receiver (3) is in analyte-exchangeable contact with the reagent compartment (1);

b) bringing said sample receiver (3) in contact with the sample;

c) bringing the reagent compartment (1) and the sample receiver (3) in the second position thereby allowing exchange of analyte and/or reagents between the reagent compartment (1) and the sample receiver (3) and allowing the occurrence of a reaction between analyte and reagents and the formation of a detectable product; and

d) determining the presence of the analyte in the liquid sample by visual inspection of the reagent compartment (1) and/or the sample receiver (3) for the presence of the detectable product.

14. Method according to claim 13, wherein said sample receiver (3) is brought in contact with the sample by the use of a probing element (15) or sample uptake element (18) provided on the test device.