Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates

• US 20040254565A1
• Filed: 06/12/2003
• Published: 12/16/2004
• Est. Priority Date: 06/12/2003
• Status: Active Grant

• Current Assignee: Cardinal Health Switzerland 515 GmbH (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Russell, Scott M.
• Granted Patent: US 6,976,983 B2
• Time in Patent Office: Days
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: G05D 7/0186 without moving parts

Abstract

An implantable device for delivering a drug includes a housing and a source of drug contained within the housing. An orifice mechanism is located at the housing and communicates with the source of drug. The orifice mechanism includes an inner member having a proximal end and a distal end and a winding helically wound around the inner member. The winding and the inner member define a first channel for carrying the drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding. The drug is carried by the orifice mechanism and dispensed outside of the housing.

Claims

1. An implantable device for delivering a drug comprising:

a housing;

a source of drug contained within the housing;

an orifice mechanism at the housing and communicating with the source of drug, the orifice mechanism comprising;

(i) an inner member having a proximal end and a distal end;

(ii) a winding helically wound around the inner member;

(iii) the winding and the inner member defining a first channel for carrying the drug therethrough and an inlet at the proximal end of the winding and an outlet at the distal end of the winding; and

the drug being carried by the orifice mechanism and dispensed outside of the housing.

2. The implantable device according to claim 1, further comprising a driving system for moving the drug to the inlet of the orifice device.

3. The implantable device according to claim 2, wherein the driving system comprises a movable interface.

4. The implantable device according to claim 3, wherein the driving system further comprises a swellable element abutting the movable interface.

5. The implantable device according to claim 4, wherein the housing is a semi-permeable membrane communicating with the swellable element.

6. The implantable device according to claim 5, wherein the driving system further comprises a densifier.

7. The implantable device according to claim 6, wherein the densifier includes a space and the orifice mechanism is located within the space.

8. The implantable device according to claim 1, wherein the housing includes an opening communicating with the outlet of the orifice mechanism.

9. The implantable device according to claim 1, wherein the winding further comprises a wire.

10. The implantable device according to claim 9, further comprising an outer member over the winding.

11. The implantable device according to claim 10, wherein the winding and the outer member define a second channel for also carrying a drug therethrough.

12. The implantable device according to claim 11, wherein the outer member comprises channel filling material for blocking drug flow through the second channel.

13. The implantable device according to claim 9, wherein the wire has a circular shape in cross-section.

14. The implantable device according to claim 11, wherein the wire has a circular shape in cross-section.

15. The implantable device according to claim 9, wherein the wire has a hexagonal shape in cross-section.

16. The implantable device according to claim 10, wherein the wire has a hexagonal shape in cross-section.

17. The implantable device according to claim 9, wherein the wire has an octagonal shape in cross-section.

18. The implantable device according to claim 11, wherein the wire has an octagonal shape in cross-section.

19. The implantable device according to claim 9, wherein the wire has a triangular shape in cross-section.

20. The implantable device according to claim 10, wherein the outer member is a sleeve.

21. The implantable device according to claim 10, wherein the outer member is made of a polymer material.

22. The implantable device according to claim 21, wherein the polymer material is PTFE.

23. The implantable device according to claim 12, wherein the channel filling material is a glue.

24. The implantable device according to claim 9, wherein the wire is made of a degradation-resistant material.

25. The implantable device according to claim 24, wherein the material is a nickel titanium alloy.

26. The implantable device according to claim 24, wherein the material is a stainless steel alloy.

27. The implantable device according to claim 24, wherein the material is plastic.

28. The implantable device according to claim 9, wherein the wire has a width ranging from 0.001-0.050 inches.

29. The implantable device according to claim 28, wherein the wire has a width ranging from 0.004-0.005 inches.