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Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs

  • US 20040255956A1
  • Filed: 06/16/2004
  • Published: 12/23/2004
  • Est. Priority Date: 12/21/2001
  • Status: Abandoned Application
First Claim
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1. A method of preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue, comprising the following steps:

  • a) stopping perfusion of the organ for from about 5 seconds to about 5 minutes;

    b) resuming perfusion of the organ for from about 5 seconds to about 5 minutes;

    c) repeating steps a) and b) sequentially for from about 2 to about 50 times; and

    d) allowing uninterrupted perfusion of the organ or tissue, thereby preventing injury to the organ or tissue in the subject following an ischemic event.

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