Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
First Claim
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1. A method of preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue, comprising the following steps:
- a) stopping perfusion of the organ for from about 5 seconds to about 5 minutes;
b) resuming perfusion of the organ for from about 5 seconds to about 5 minutes;
c) repeating steps a) and b) sequentially for from about 2 to about 50 times; and
d) allowing uninterrupted perfusion of the organ or tissue, thereby preventing injury to the organ or tissue in the subject following an ischemic event.
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Abstract
The present invention provides a method of post-conditioning reperfusion of an organ or tissue injured by ischemia. Also provided is a method of treating a myocardial infarction in a subject to prevent injury to the heart following reperfusion of the heart.
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Citations
26 Claims
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1. A method of preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue, comprising the following steps:
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a) stopping perfusion of the organ for from about 5 seconds to about 5 minutes;
b) resuming perfusion of the organ for from about 5 seconds to about 5 minutes;
c) repeating steps a) and b) sequentially for from about 2 to about 50 times; and
d) allowing uninterrupted perfusion of the organ or tissue, thereby preventing injury to the organ or tissue in the subject following an ischemic event. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of preventing injury to a heart in a subject diagnosed with an ischemic event of the heart, comprising:
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a) clearing a lumen of a coronary artery;
b) perfusing the heart for from about 5 seconds to about 5 minutes;
c) stopping perfusion of the heart for from about 5 seconds to about 5 minutes;
d) repeating steps b) and c) sequentially for from about 2 to about 50 times; and
e) allowing uninterrupted perfusion of the heart, thereby preventing injury to the heart in the subject. - View Dependent Claims (10, 11, 12, 13)
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14. A method of preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue, comprising the following steps:
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a) reducing perfusion of the organ for from about 5 seconds to about 5 minutes;
b) resuming perfusion of the organ for from about 5 seconds to about 5 minutes;
c) repeating steps a) and b) sequentially for from about 2 to about 50 times; and
d) allowing uninterrupted perfusion of the organ or tissue, thereby preventing injury to the organ or tissue in the subject following an ischemic event. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method of preventing injury to a heart in a subject diagnosed with an ischemic event of the heart, comprising:
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a) clearing a lumen of a coronary artery;
b) perfusing the heart for from about 5 seconds to about 5 minutes;
c) reducing perfusion of the heart for from about 5 seconds to about 5 minutes;
d) repeating steps b) and c) sequentially for from about 2 to about 50 times; and
e) allowing uninterrupted perfusion of the heart, thereby preventing injury to the heart in the subject. - View Dependent Claims (23, 24, 25, 26)
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Specification