System and method for synthesis of molecular imaging probes including FDG
First Claim
1. A method for producing a radiochemical solution in a microfluidic environment, the method comprising:
- i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) providing a precursor solution and introducing the precursor solution into the first inlet port of the micro reactor, wherein the precursor solution comprises a reactive precursor adapted for reaction with a radioactive isotope and is dissolved in an organic solvent;
iii) providing an radioactive solution and introducing the radioactive solution into the second inlet port of the micro reactor, wherein the radioactive solution comprises a radioactive isotope dissolved in an organic solvent; and
iv) uniting the precursor solution with the radioactive solution in the at least one microchannel of the micro reactor enabling the reactive precursor to react with the radioactive isotope as the precursor solution and radioactive solution flow in the microchannel to form a radiochemical in solution.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises providing a micro reactor, providing a precursor solution and introducing the precursor solution into the micro reactor, wherein the precursor solution comprises a reactive precursor adapted for reaction with a radioactive isotope and dissolved in an organic solvent, providing a radioactive solution and introducing the radioactive solution into the micro reactor, wherein the radioactive solution comprises a radioactive isotope dissolved in an organic solvent, and uniting the precursor solution with the radioactive solution in a microchannel of the micro reactor enabling the reactive precursor to react with the radioactive isotope as the precursor solution and radioactive solution flow in the microchannel to form a radiochemical in solution.
49 Citations
40 Claims
-
1. A method for producing a radiochemical solution in a microfluidic environment, the method comprising:
-
i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) providing a precursor solution and introducing the precursor solution into the first inlet port of the micro reactor, wherein the precursor solution comprises a reactive precursor adapted for reaction with a radioactive isotope and is dissolved in an organic solvent;
iii) providing an radioactive solution and introducing the radioactive solution into the second inlet port of the micro reactor, wherein the radioactive solution comprises a radioactive isotope dissolved in an organic solvent; and
iv) uniting the precursor solution with the radioactive solution in the at least one microchannel of the micro reactor enabling the reactive precursor to react with the radioactive isotope as the precursor solution and radioactive solution flow in the microchannel to form a radiochemical in solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. A method for synthesizing a fluoride-18 labeled radiochemical in a microfluidic environment, the method comprising:
-
i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port;
ii) providing an organic reactive precursor solution and introducing the organic reactive precursor solution into the first inlet port of the micro reactor, wherein the organic reactive precursor solution comprises a reactive precursor dissolved in an organic solvent and is adapted for reaction with fluoride-18;
iii) providing a fluoride-18 solution and introducing the fluoride-18 solution into the second inlet port of the micro reactor, wherein the fluoride-18 solution comprises fluoride-18 dissolved in an organic solvent; and
iv) uniting the organic reactive precursor solution with the fluoride-18 solution in a confluence of the at least one microchannel of the micro reactor thereby enabling the reactive precursor to react with the fluoride-18 as the organic reactive precursor solution and the fluoride-18 solution flow in the microchannel to form a fluoride-18 labeled radiochemical in solution. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
-
Specification