Biomolecular substrate and method and apparatus for examination and diagnosis using the same
First Claim
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1. A method for fabricating a biomolecule substrate, comprising the steps of:
- 1) providing a set of biomolecules and a substrate;
2) enclosing the set of biomolecules into microcapsules on the biomolecule-type-by-biomolecule-type basis; and
3) spraying the biomolecule microcapsules onto the substrate.
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Abstract
An object of the present invention is to provide a test apparatus for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. The above-described problem was solved by providing a substrate on which a plurality of biomolecule spots containing a group of biomolecules (e.g., DNA, etc.) of a specific type are formed, where the pattern or position of the DNA spot is changed depending on specific data so that information of the specific data is recorded on the substrate.
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Citations
93 Claims
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1. A method for fabricating a biomolecule substrate, comprising the steps of:
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1) providing a set of biomolecules and a substrate;
2) enclosing the set of biomolecules into microcapsules on the biomolecule-type-by-biomolecule-type basis; and
3) spraying the biomolecule microcapsules onto the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88)
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12. A biomolecule chip, comprising:
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a substrate; and
biomolecules and chip attribute data arranged on the substrate, wherein the chip attribute data is arranged in the same region as that of the biomolecules. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 92, 93)
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27. A biomolecule chip, comprising:
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1) a substrate; and
2) biomolecules arranged on the substrate, wherein spots of the biomolecules are spaced by at least one non-equal interval, an address of the biomolecule spot can be identified from the non-equal interval. - View Dependent Claims (28, 29, 31, 32, 33, 34, 35, 36, 37, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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30. A biomolecule chip, comprising:
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1) a substrate; and
2) biomolecules arranged on the substrate, wherein the biomolecules include a distinguishable first biomolecule and a distinguishable second biomolecule, an address of the biomolecule can be identified based on an arrangement of spots of the first biomolecules and spots of the second biomolecule.
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38. A biomolecule chip, comprising:
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1) a substrate; and
2) biomolecules arranged on the substrate, wherein spots storing attribute data are arranged on a side of the substrate opposite to a side on which spots of the biomolecules are arranged. - View Dependent Claims (39)
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40. A biomolecule chip, comprising:
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1) a substrate;
2) biomolecules arranged on the substrate; and
3) a data recording region. - View Dependent Claims (41)
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42. A method for detecting a label of a biomolecule chip, comprising the steps of:
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1) providing a biomolecule chip on which at least one labeled biomolecule is arranged;
2) switching detection elements sequentially for detecting the biomolecules on the biomolecule chip; and
3) identifying a signal detected by the detection element. - View Dependent Claims (43, 44, 45, 46)
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89. A test apparatus for biological information, comprising:
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a support for a substrate;
a plurality of groups of biomolecules arranged on the substrate, each group containining the biomolecules of the same type;
shifting means for shifting the substrate;
a light source for exciting a fluorescence substance labeling a sample to be tested; and
optical means for converging light from the light source, wherein the light source is caused to emit light intermittently in response to an intermittent emission signal so as to excite the fluorescence substance, fluorescence from the fluorescence substance is detected by a photodetector during a period of time when the intermittent emission signal is paused, identification information is reproduced from an arrangement of the DNAs, and the biomolecules emitting fluorescence is identified. - View Dependent Claims (90, 91)
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Specification