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Method for diagnosing and treating breast cancer

  • US 20040259144A1
  • Filed: 05/27/2004
  • Published: 12/23/2004
  • Est. Priority Date: 05/27/2003
  • Status: Abandoned Application
First Claim
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1. A method of evaluating an expected time to recurrence of a breast cancer in a patient, the method comprising the steps of:

  • (a) providing numerical data for a plurality of observed times to recurrence and an associated plurality of nuclear pleomorphic features comprising;

    radius;

    texture;

    perimeter;

    area;

    smoothness;

    compactness;

    concavity;

    concave points;

    symmetry; and

    fractal dimension;

    (b) performing a nonlinear regression on the numerical data to select a coefficient for each of the plurality of nuclear pleomorphic features, such that the selected coefficients provide a local extreme in the correlation to the corresponding times to recurrence;

    (c) measuring at least two of the plurality of nuclear pleomorphic features in tumor tissue of the patient; and

    (d) calculating a prognostic index by multiplying each of the at least two measured pleomorphic features in tumor tissue of the patient by the corresponding coefficients selected in step (b).

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