Combination therapy for constipation
First Claim
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1. A method for treating constipation comprising administering to a patient in need of such treatment a laxative and a peripheral opioid antagonist in amounts effective to treat the constipation.
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Abstract
Methods for treating constipation are provided. The methods include administration of peripheral opioid antagonists in combination with laxatives and/or stool softeners. Patients treatable by the invention include those refractory to conventional laxative and stool softener therapy.
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Citations
114 Claims
- 1. A method for treating constipation comprising administering to a patient in need of such treatment a laxative and a peripheral opioid antagonist in amounts effective to treat the constipation.
- 7. A method for treating constipation comprising administering to a patient in need of such treatment a stool softener and a peripheral opioid antagonist in amounts effective to treat the constipation.
- 13. A method for treating a condition calling for treatment with a laxative comprising administering to a patient in need of such treatment a laxative and a peripheral opioid antagonist in amounts effective to treat the condition.
- 19. A method for treating a condition for treatment with a stool softener comprising administering to a patient in need of such treatment a stool softener and a peripheral opioid antagonist in amounts effective to treat the condition.
- 48. A formulation comprising a peripheral opioid antagonist and a laxative.
- 80. A formulation comprising a peripheral opioid antagonist and a stool softener.
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112. A kit comprising:
a package containing a formulation of a peripheral opioid antagonist and a laxative and/or a stool softener. - View Dependent Claims (114)
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113. (canceled)
Specification