Analysis system for reagent-free determination of the concentration of an analyte in living tissue
First Claim
1. A system for the reagent-free determination of the concentration of an analyte in living tissue of a patient, the system comprising:
- a light transmitter for generating monochromatic primary light;
a scattered-light percutaneous sensor inserted through the skin surface into the skin, wherein a distal end of the percutaneous sensor has a sensor head such that the sensor head pierces the skin;
an inbound light guide in which primary light is conducted through the skin surface into the interior of the body;
a light irradiation surface formed at a distal end of the inbound light guide through which the primary light penetrates into a test volume of the tissue;
a detection light guide which has at its distal end includes a light receiving surface through which a secondary light scattered in the test volume penetrates into the detection light guide;
a wavelength-sensitive detection device connected to the detection light guide for detection of Raman-scattered components of the secondary light; and
an evaluation device for determining the concentration of the analyte from the Raman-scattered components of the secondary light.
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Abstract
The present invention is generally directed towards a system for reagent-free determination of the concentration of an analyte in vivo. The system comprises a light transmitter for generating monochromatic primary light, a scattered-light percutaneous sensor which includes an inbound light guide and a detection light guide, a wavelength-selective detection device that is connected to the detection light guide for detection of Raman-scattered components of the secondary light and an evaluation device for determining the concentration of the analyte from the Raman-scattered components of the secondary light.
46 Citations
20 Claims
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1. A system for the reagent-free determination of the concentration of an analyte in living tissue of a patient, the system comprising:
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a light transmitter for generating monochromatic primary light;
a scattered-light percutaneous sensor inserted through the skin surface into the skin, wherein a distal end of the percutaneous sensor has a sensor head such that the sensor head pierces the skin;
an inbound light guide in which primary light is conducted through the skin surface into the interior of the body;
a light irradiation surface formed at a distal end of the inbound light guide through which the primary light penetrates into a test volume of the tissue;
a detection light guide which has at its distal end includes a light receiving surface through which a secondary light scattered in the test volume penetrates into the detection light guide;
a wavelength-sensitive detection device connected to the detection light guide for detection of Raman-scattered components of the secondary light; and
an evaluation device for determining the concentration of the analyte from the Raman-scattered components of the secondary light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification