Automated auscultation system
First Claim
1. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
- (a) selecting one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) performing a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle; and
(c) processing the information to reach a clinically relevant conclusion or recommendation; and
(d) presenting some or all of the information in a manner that facilitates a mechanistically comprehensible explanation of the basis for the conclusion or recommendation or how the conclusion or recommendation was reached.
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Accused Products
Abstract
The present invention provides systems and methods for performing automated auscultation and diagnosis of conditions of the cardiovascular system. The invention acquires an acoustic signal emanating from the cardiovascular system via an sensor. In addition, in certain embodiments of the invention an electrical signal, e.g., an electrocardiogram (EKG) is simultaneously acquired. The signals are digitized, and, optionally, filtered to remove noise. The invention then processes and analyses the signal(s) so as to provide a clinically relevant conclusion or recommendation such as a diagnosis or suggested additional tests or therapy. In preferred embodiments the system comprises: (1) a beat selection component that selects a plurality of beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system; (2) a time-frequency analysis component that performs a time-frequency decomposition of beats selected for analysis so as to identify or extract physiologically relevant features; and (3) a processing component that processes the information so at to provide a clinically relevant conclusion or recommendation. In preferred embodiments of the invention the system further includes an aggregation component that combines information obtained from a plurality of the beats selected for analysis. In one embodiment, the system diagnoses mitral valve prolapse.
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Citations
75 Claims
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1. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
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(a) selecting one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) performing a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle; and
(c) processing the information to reach a clinically relevant conclusion or recommendation; and
(d) presenting some or all of the information in a manner that facilitates a mechanistically comprehensible explanation of the basis for the conclusion or recommendation or how the conclusion or recommendation was reached. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
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(a) selecting one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) performing a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle;
(c) combining information obtained from a plurality of the beats selected for analysis; and
(d) processing the information to reach a clinically relevant conclusion or recommendation, wherein the step of performing a time-frequency analysis, the processing step, or both make use of knowledge of the physiological or mechanistic basis of a disease or clinical condition of the cardiovascular system. - View Dependent Claims (10)
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11. A method of performing automated auscultation of the cardiovascular system of a subject, the method comprising steps of:
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(a) selecting one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) performing a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle;
(c) if more than one beat was selected in step (a), combining information obtained from a plurality of the beats selected for analysis; and
(d) processing the information to reach a clinically relevant conclusion or recommendation. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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54. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
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(a) selecting a plurality of beats;
(b) constructing a prototypical beat by combining information from the plurality of beats;
(c) computing a metric that characterizes the prototypical beat; and
(d) classifying the prototypical beat as indicative of the presence or absence of a disease or condition, or of its severity, by comparing the metric computed in step (c) with a value for the metric characteristic of a normal subject. - View Dependent Claims (55, 56)
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57. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
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(a) selecting a plurality of beats;
(b) constructing a prototypical beat by combining information from the plurality of beats; and
(c) presenting the prototypical beat, a time-frequency decomposition of the prototypical beat, or both, to a user, wherein presenting the prototypical beat comprises displaying an image of the beat, playing a recording of the beat or an enhanced version thereof, or both.
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58. A method of performing automated auscultation of the cardiovascular system, the method comprising steps of:
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(a) selecting one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) performing a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle; and
(c) presenting information derived at least in part from the acoustic signal, wherein the information comprises one or more items selected from the group consisting of;
a visual or audio presentation of a prototypical beat, a display of the time-frequency decomposition of one or more beats or prototypical beats, and a playback of the acoustic signal at a reduced rate with preservation of frequency content, wherein any of the foregoing items may be annotated or unannotated.
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59. A system for performing automated auscultation of the cardiovascular system, the system comprising:
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(a) a beat selection component that selects one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) a time-frequency analysis component that provides information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle; and
(c) a diagnostic module that processes the information to as to reach a clinically relevant conclusion or recommendation; and
(d) a presentation component that presents some or all of the information in a manner that facilitates a mechanistically comprehensible explanation of the basis for the conclusion or recommendation or how the conclusion or recommendation was reached. - View Dependent Claims (61, 62, 63, 69)
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60. A system for performing automated auscultation of the cardiovascular system of a subject, the method comprising steps of:
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(a) a beat selection component that selects one or more beats for analysis, wherein each beat comprises an acoustic signal emanating from the cardiovascular system;
(b) a time-frequency analysis component that performs a time-frequency analysis of beats selected for analysis so as to provide information regarding the distribution of energy, the relative distribution of energy, or both, over different frequency ranges at one or more points in the cardiac cycle;
(c) an aggregation component that combines information obtained from a plurality of the beats selected for analysis; and
(d) a diagnostic module that processes the information to reach a clinically relevant conclusion or recommendation. - View Dependent Claims (64, 65, 66)
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67. A system for assisting in the clinical evaluation of a subject'"'"'s cardiovascular system comprising:
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an apparatus for performing automated auscultation of the cardiovascular system of a subject, wherein the apparatus analyzes an acoustic signal emanating from the cardiovascular system and provides a clinically relevant conclusion or recommendation; and
at least one audio-visual diagnostic aid that presents information derived at least in part from the acoustic signal. - View Dependent Claims (70, 71, 72, 73, 74, 75)
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68. A system for assisting in the clinical evaluation of a subject'"'"'s cardiovascular system comprising:
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an apparatus for performing automated auscultation of the cardiovascular system of a subject; and
at least one audio-visual diagnostic aid that presents information derived at least in part from the acoustic signal, wherein the information comprises one or more items selected from the group consisting of;
a visual or audio presentation of a prototypical beat, a display of the time-frequency decomposition of one or more beats or prototypical beats, and a playback of the acoustic signal at a reduced rate with preservation of frequency content, wherein any of the foregoing items may be annotated or unannotated.
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Specification