Apparatus and methods for repetitive microjet durg delivery priority statement
First Claim
Patent Images
1. An active, fluid delivery system, comprising:
- a support structure;
at least one exit orifice defined in the support structure, said orifice having a diameter between about 1 μ
m and about 500 μ
m;
a fluid reservoir configured to contain a fluid to be delivered to a tissue and communicating with said at least one exit orifice; and
repeatable activation means cooperating with said fluid reservoir and said at least one exit orifice for ejection of fluid in response to an activation signal.
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Abstract
An active, transdermal delivery system includes a support structure and a fluid reservoir within the support structure configured to contain a fluid to be delivered transdermally. There is also at least one exit orifice defined in the support structure that is in communication with the fluid reservoir. The orifice has a diameter of between about 1 μm and 500 μm. Furthermore, a repeatable activation means is disposed within the support structure and is in cooperation with the exit orifice for ejection of fluid in response to an activation signal.
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Citations
63 Claims
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1. An active, fluid delivery system, comprising:
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a support structure;
at least one exit orifice defined in the support structure, said orifice having a diameter between about 1 μ
m and about 500 μ
m;
a fluid reservoir configured to contain a fluid to be delivered to a tissue and communicating with said at least one exit orifice; and
repeatable activation means cooperating with said fluid reservoir and said at least one exit orifice for ejection of fluid in response to an activation signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. An active, fluid delivery system, comprising:
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a support structure;
a fluid ejection chamber within the support structure;
at least one exit orifice defined in the support structure and communicating with the fluid ejection chamber; and
activation means disposed in the fluid ejection chamber, wherein said fluid ejection chamber, at least one exit orifice, and activation means are configured and dimensioned together for continuously cyclic repeatable ejection of fluid in the range of about 1 pl to about 800 nl. - View Dependent Claims (39, 40, 41, 42, 43)
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44. An active, fluid delivery system, comprising:
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a support structure;
a fluid ejection chamber within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and communicating with the fluid ejection chamber;
activation means disposed in the fluid ejection chamber; and
a controller programmed to activate the activation means to deliver a sustained repetitive administration regime from not less than about 500 ms to not more than about 10 days. - View Dependent Claims (45, 46, 47)
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48. An active, fluid delivery system, comprising:
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a support structure;
a fluid reservoir within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and communicating with the fluid reservoir; and
a piezoelectric mechanism that mechanically deform upon application of a voltage, the piezoelectric mechanism being disposed within the support structure in cooperation with the at least one exit orifice for ejection of fluid in response to an activation signal.
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49. An active, transdermal delivery system, comprising:
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a support structure;
a fluid reservoir within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and communicating with the fluid reservoir; and
a phase change mechanism that vaporizes an actuation fluid in response to an activation signal, thereby generating a pressure change in the fluid and ejecting fluid from the exit orifice.
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50. An active, transdermal delivery system, comprising:
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a support structure;
a fluid reservoir within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and in communication with the fluid reservoir; and
a phase change mechanism that vaporizes at least some of the fluid in response to an activation signal, thereby generating a pressure change in the fluid and ejecting a portion of the fluid from the exit orifice. - View Dependent Claims (51, 52)
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53. An active, transdermal delivery system, comprising:
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a support structure;
a fluid reservoir within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and communicating with the fluid reservoir; and
an electromagnetic mechanism disposed within the fluid reservoir in cooperation with the at least one exit orifice for ejection fluid in response to an activation signal.
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54. An active, transdermal delivery system, comprising:
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a support structure;
a fluid reservoir within the support structure configured to contain a fluid to be delivered;
at least one exit orifice defined in the support structure and communicating with the fluid reservoir; and
a high pressure hydraulic mechanism disposed within the support structure in cooperation with the at least one exit orifice for ejection of fluid in response to an activation signal.
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55. An active, fluid delivery system having a support structure configured and dimensioned with an array of administration chambers, wherein each administration chamber comprises:
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a exit orifice defined in the support structure, said exit orifice having a diameter between about 1 μ
m and about 500 μ
m;
a fluid reservoir configured to contain a fluid to be delivered to a tissue, wherein said fluid reservoir is in communication with said exit orifice; and
a repeatable activation means cooperating with said fluid reservoir and said exit orifice for ejection of fluid in response to an activation signal.
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56. A method for active, transdermal delivery, comprising:
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positioning a support structure defining an orifice adjacent a biological tissue, said orifice having a diameter of between about 1 μ
m and about 500 μ
m, and said support structure in fluid communication with a fluid to be administered to the biological tissue; and
actively and repetitively ejecting fluid into the biological tissue. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63)
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Specification