Method and system for intravesicular delivery of therapeutic agents
First Claim
1. A therapeutic agent delivery implant for implantation into a patient'"'"'s body, said implant comprising:
- a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold and one or more therapeutic agents secured to and/or supported by the scaffold for release within the patient.
1 Assignment
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Accused Products
Abstract
A therapeutic agent delivery implant for implantation into a patient'"'"'s body comprises a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold; and a hydrophilic coating arranged on said scaffold, wherein said coating contains one or more therapeutic agents for release within the patient. Optionally the coating can contain microspheres or enzymes. In a preferred embodiment, the scaffold comprises a hydrophobic polyurethane, the coating comprises a hydrophilic polyurethane, and the implant has a hemispherical, bullet, football, cylindrical, spherical, or irregular shape. The implant can be delivered through a rigid or flexible delivery instrument that deploys the implant at a desirable site, whereby the implant expands to a size and shape substantially similar to its size and shape before insertion.
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Citations
59 Claims
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1. A therapeutic agent delivery implant for implantation into a patient'"'"'s body, said implant comprising:
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a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold and one or more therapeutic agents secured to and/or supported by the scaffold for release within the patient. - View Dependent Claims (4, 5, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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2. A therapeutic agent delivery implant for implantation into a patient'"'"'s body, said implant comprising:
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a resilient or flexible, at least partially hydrophobic reticulated elastomeric support scaffold; and
a hydrophilic coating arranged on said scaffold, wherein said coating contains one or more therapeutic agents for release within the patient. - View Dependent Claims (3, 6, 7, 9)
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44. A therapeutic agent delivery implant for implantation to a mammalian site, the implant comprising:
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a resilient or flexible,hydrophobic support reticulated elastomeric scaffold and at least one therapeutic agent secured to and supported by the scaffold for release at the mammalian site, wherein the therapeutic agent delivery implant is insertable into a mammalian bladder or other suitable site via the urethra and is locatable within the bladder. - View Dependent Claims (45, 46, 47, 48, 49, 50)
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51. A method of delivering an implant to a mammalian site comprising the steps of:
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(a) collapsing and/or loading into a delivery instrument a resiliently compressible therapeutic agent delivery implant having an expanded configuration when deployed;
(b) advancing the delivery instrument through a mammalian urethra to access the bladder;
(c) deploying the therapeutic agent delivery implant through the delivery instrument into the bladder; and
(d) withdrawing the delivery instrument, leaving the therapeatic agent delivery implant in the bladder. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59)
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Specification