Hybrid random bead/chip based microarray
First Claim
1. An optical identification element attached to a chemical, comprising:
- an optical substrate;
at least a portion of said substrate having at least one diffraction grating disposed therein, said grating having at least one refractive index pitch superimposed at a common location;
the grating providing an output optical signal when illuminated by an incident light signal;
said optical output signal being indicative of a code in said substrate; and
the chemical being attached to said substrate.
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Accused Products
Abstract
A hybrid random bead/chip based microarray includes a plurality of loose optical identification elements (or beads) comprising a substrate having at least one identifiable code disposed thereon. The are randomly placed on a substrate, e.g., tray, plate, slide, or “chip” in an identifiable position (or location) on the slide (not necessarily immobily fixed). For example, the beads are randomly distributed (but oriented) in one dimension along grooves in the slide. Then, each bead code is read and its location determined, i.e., the bead code and location are mapped to its location on the chip. The beads on the chip may then be read/examined (and re-read if desired) by a conventional chip reader. The beads may be functionalized with a desired probe and/or reacted with a desired analyte when in the loose state and/or when on the chip. After reading the chip, the beads may be removed from the chip for further or alternative processing.
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Citations
19 Claims
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1. An optical identification element attached to a chemical, comprising:
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an optical substrate;
at least a portion of said substrate having at least one diffraction grating disposed therein, said grating having at least one refractive index pitch superimposed at a common location;
the grating providing an output optical signal when illuminated by an incident light signal;
said optical output signal being indicative of a code in said substrate; and
the chemical being attached to said substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A microparticle attached to a chemical comprising:
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an optical substrate;
at least a portion of said substrate having at least one diffraction grating disposed therein, said grating having at least one refractive index pitch superimposed at a common location;
the grating providing an output optical signal when illuminated by an incident light signal;
said optical output signal being indicative of a code in said substrate; and
the chemical being attached to said substrate.
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19. A method of performing a multiplexed experiment, comprising:
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obtaining an optical substrate at least a portion of which having a diffraction grating with one or more refractive index pitches superimposed at a common location;
attaching a chemical to said substrate;
illuminating said substrate with incident light, said substrate providing an output light signal; and
reading said output light signal and detecting a code therefrom.
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Specification