Method for coating skin piercing microprojections
First Claim
1. A transdermal delivery device for delivering a biologically active agent comprising at least one stratum corneum-piercing microprojection, wherein said microprojection has a first portion with a hydrophobic coating and a second portion with a hydrophilic coating comprising said biologically active agent.
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Accused Products
Abstract
An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections. The coating solution is applied to the skin piercing microprojections using a coating technique which selectively coats only predetermined portions the skin piercing microprojections. By the use of various photoresists and hydrophobic coatings, a defined and precise portion of the microprojections and/or the microprojection arrays can be coated with an agent formulation.
123 Citations
60 Claims
- 1. A transdermal delivery device for delivering a biologically active agent comprising at least one stratum corneum-piercing microprojection, wherein said microprojection has a first portion with a hydrophobic coating and a second portion with a hydrophilic coating comprising said biologically active agent.
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26. A method for forming a device for transdermally delivering a biologically active agent comprising the steps of:
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forming at least one stratum corneum-piercing microprojection in a thin sheet of material;
applying a hydrophobic coating to a first portion of said microprojection; and
applying a hydrophilic coating comprising said biologically active agent to a second portion of said microprojection. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34)
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35. A method for forming a device for transdermally delivering a biologically active agent comprising the steps of:
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providing a device having at least one microprojection configured to pierce the stratum corneum;
applying a photoresist to said device;
masking said device so that a first portion of said microprojection is covered and a second portion of said microprojection is exposed;
exposing said masked device to radiation;
washing unexposed photoresist from said first portion of said microprojection;
applying a hydrophobic coating to said first and second portions of said microprojection;
solubilizing exposed photoresist on said second portion;
washing solubilized photoresist from said second portion to remove said hydrophobic coating from said second portion; and
applying a hydrophilic coating comprising said biologically active agent to said second portion of said microprojection.
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- 36. A transdermal delivery device for delivering a biologically active agent comprising a microprojection array of a plurality of stratum corneum-piercing microprojections, wherein at least a portion of each of said microprojections has a hydrophilic coating comprising said biologically active agent and a portion of said device has a hydrophobic coating.
Specification