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Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors

  • US 20040265912A1
  • Filed: 05/20/2004
  • Published: 12/30/2004
  • Est. Priority Date: 05/23/2003
  • Status: Active Grant
First Claim
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1. A bead-based method for identifying both thioaptamer sequences and binding proteins comprising the steps of:

  • incubating a thioaptamer library with a sample suspected of comprising one or more proteins;

    selecting the one or more thioaptamers of the library to which protein has bound;

    identifying the proteins by mass spectrometry; and

    identifying the thioaptamer by PCR, cloning and sequencing.

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