Multicapillary fraction collection system and method
First Claim
Patent Images
1. A system comprising:
- a separation pathway having a first end and a second end;
a sample well in communication with the first end;
one or more collection wells, wherein the second end is adapted to communicate with at least one collection well of the one or more collection wells;
a power supply having a first electrode and a second electrode adapted to create an electric field between the first end and the second end;
a first actuator adapted to adjust a first position of the second end relative to the plurality of collection wells; and
a controller coupled to the first actuator and adapted to modulate a potential between the first end and the second end and adapted to control the first position.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of injecting, isolating and separating mixed analytes from one or more samples. The method includes collecting successive fractions from each of a plurality of samples at discrete points in time. Fractions may be analyzed at the time of collecting, or later, using one or more detector systems. In one embodiment, a processor controls the elutions of fractions by modulating the migration field in a separation pathway. The processor also controls distribution of the fraction into a particular collection well of a plurality of collection wells.
34 Citations
44 Claims
-
1. A system comprising:
-
a separation pathway having a first end and a second end;
a sample well in communication with the first end;
one or more collection wells, wherein the second end is adapted to communicate with at least one collection well of the one or more collection wells;
a power supply having a first electrode and a second electrode adapted to create an electric field between the first end and the second end;
a first actuator adapted to adjust a first position of the second end relative to the plurality of collection wells; and
a controller coupled to the first actuator and adapted to modulate a potential between the first end and the second end and adapted to control the first position. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A computer implemented method comprising:
-
applying a sample to an input of a separation pathway;
generating a migratory field in the separation pathway;
eluting an analyte of the sample from the separation pathway;
collecting the analyte in a collection well;
interrupting the migratory field after collecting commences; and
repeating the collecting and the interrupting, at a predetermined time interval, for a successive analtye and a successive collection well. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
-
-
33. A system comprising:
-
a plurality of separation pathways, each separation pathway having a first end and a second end;
a plurality of sample wells, wherein each sample well is in communication with a first end of a separation pathway;
a power supply having a first electrode and a second electrode adapted to create an electric field between the first end and the second end of each separation pathway;
for each separation pathway, a plurality of collection wells wherein each collection well is adapted to communicate with a second end of the separation pathway;
for each separation pathway, a first actuator adapted to adjust a position of the second end relative to the plurality of collection wells; and
a controller coupled to the first actuator and adapted to modulate the electric field and adapted to control the position. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
-
Specification