Composition for treatment of infections of humans and animals

• US 20040266888A1
• Filed: 11/17/2003
• Published: 12/30/2004
• Est. Priority Date: 09/01/1999
• Status: Abandoned Application

• Current Assignee: Van BEEK Global LLC
• Original Assignee: Van BEEK Global/Ninkov LLC
• Inventors: Ninkov, Dusan
• Application Number:
  US10/715,886
• Publication Number:
  US 20040266888A1
• Time in Patent Office: Days
• US Class Current: 514/731
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 36/23 Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• CPC Class Codes: A61K 36/53 Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/534 Mentha (mint)
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/67 Piperaceae (Pepper family), e.g. Jamaican pepper or kava
• CPC Class Codes: A61K 36/75 Rutaceae (Rue family)
• CPC Class Codes: A61K 36/85 Verbenaceae (Verbena family)
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: B01F 2035/99 Heating
• CPC Class Codes: B01F 2215/0472 Numerical temperature values
• CPC Class Codes: B01F 2215/0477 Numerical time values
• CPC Class Codes: B01F 2215/0481 Numerical speed values
• CPC Class Codes: B01F 27/91 with propellers
• CPC Class Codes: B01F 35/92 for heating the outside of the receptacle, e.g. heated jackets or burners
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

This disclosure provides pharmaceutical compositions which include oil extract from plants from the Labiatae family. In particular, the compositions can be formulated by combining extracts of essential oils from plants of the Labiatae family with an organic acid or a Group I salt. It is believed that the antimicrobial activity of the pharmaceutical composition is due to the presence of organic phenols, such as isopropyl-o-cresol, in the oil extract from the plants.

Claims

1. A pharmaecutical composition for treating a microbial infection in an animal, said composition comprising:

(a) antimicrobial compound, wherein said antimicrobial compound comprises an organic phenolic compound chemically reacted with a Group I salt; and

(b) a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1 wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.

3. The pharmaceutical composition of claim 1 wherein the Group I salt is a Group I chloride salt.

4. The pharmaceutical composition of claim 3 wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.

5. The pharmaceutical composition of claim 1 wherein the antimicrobial compound comprises isopropyl-o-cresol and isopropyl-cresol chemically reacted with sodium chloride and potassium chloride.

6. The pharmaceutical composition of claim 1 comprising 10% antimicrobial compound.

7. The pharmaceutical composition of claim 1 wherein the antimicrobial compound comprises sodium-para-cresol, potassium-para-cresol, sodium-M-cresol and potassium-M-cresol.

8. The pharmaceutical composition of claim 1 wherein the antimicrobial compound comprises 97 wt % sodium-para-cresol and potassium-para-cresol and 3 wt % sodium-M-cresol and potassium-M-cresol.

9. The pharmaceutical composition of claim 1 wherein the microbial infection is selected from the group consisting of a bacterial infection, fungal infection, protozoan infection and yeast infection.

10. The pharmaceutical composition of claim 1 wherein the animal is selected from the group consisting of humans, horses, cows, pigs, sheep, goats, rabbits, dogs, cats, chickens, turkeys, ducks and birds.

12. The method of claim 1 wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.

11. A method for treating a microbial infection in an animal, said method comprising:

(a) administering to the animal an antimicrobial compound, wherein said antimicrobial compound comprises an organic phenolic compound chemically reacted with a Group I salt.

13. The method of claim 11 wherein the Group I salt is a Group I chloride salt.

14. The method of claim 13 wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.

15. The method of claim 11 wherein the antimicrobial compound comprises isopropyl-o-cresol and isopropyl-cresol chemically reacted with sodium chloride and potassium chloride.

16. The method of claim 11 wherein the antimicrobial compound comprises sodium-para-cresol, potassium-para-cresol, sodium-M-cresol and potassium-M-cresol.

17. The method of claim 11 wherein the antimicrobial compound comprises 97 wt % sodium-para-cresol and potassium-para-cresol and 3 wt % sodium-M-cresol and potassium-M-cresol.

18. The method of claim 11 wherein the microbial infection is selected from the group consisting of a bacterial infection, fungal infection, protozoan infection and yeast infection.

19. The method of claim 11 wherein the animal is selected from the group consisting of humans, horses, cows, pigs, sheep, goats, rabbits, dogs, cats, chickens, turkeys, ducks and birds.

20. A method of preparing an antimicrobial compound, comprising:

(a) mixing an organic phenolic compound and a Group I salt in a mixer at a speed of about 200 RPM to about 2000 RPM.

21. The method of claim 20 wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.

22. The method of claim 20 wherein the Group I salt is a Group I chloride salt.

23. The method of claim 22 wherein the Group I salt is selected from the group consisting of sodium chloride, potassium chloride and combinations thereof.

24. The method of claim 20 further comprising mixing at a temperature between about 60°

C. and about 100°

C.

25. The method of claim 20 further comprising mixing for about 1 to about 20 minutes.

26. The method of claim 20 further comprising mixing for about 5 to about 15 minutes.

27. A method of preparing an antimicrobial compound comprising:

(a) mixing an organic phenolic compound and an organic acid in a mixer at a speed of about 200 RPM to about 2000 RPM.

28. The method of claim 27 wherein the organic phenolic compound is selected from the group consisting of isopropyl-o-cresol, isopropyl-cresol and combinations thereof.

29. The method of claim 27 wherein the organic acid is selected from the group consisting of propionic acid, fumaric acid, citric acid, folic acid and combinations thereof.

30. The method of claim 27 further comprising mixing at a temperature between about 60°

C. and about 100°

C.

31. The method of claim 27 further comprising mixing for about 1 to about 20 minutes.

32. The method of claim 27 further comprising mixing for about 5 to about 15 minutes.

33. An apparatus for high speed mixing, comprising:

(a) a receptacle, said receptacle comprising an inner wall, an outer wall and a base which define a cavity;

(b) a rotor which comprises a drive shaft and at least one blade;

(c) a heating element; and

(d) a motor.

34. The apparatus of claim 33 wherein the inner and outer walls of the receptacle are formed from a thermally conductive material selected from the group consisting of ceramic, metal, plastic and glass.

35. The apparatus of claim 33 wherein the inner and outer walls of the receptacle are formed from a metal.

36. The apparatus of claim 35 wherein the metal comprises stainless steel.

37. The apparatus of claim 33 wherein the inner and outer walls are spaced apart to define a gap.

38. The apparatus of claim 37 wherein the gap is configured to receive a heating element.

39. The apparatus of claim 37 wherein the gap is configured to receive a liquid.

40. The apparatus of claim 33 further comprising an input conduit and an output conduit.

41. The apparatus of claim 40 further comprising valves having open and closed positions configured and arranged to allow reactants to be fed into the cavity and product to be removed from the cavity when in an open position and obstruct passage of reactants or products when in a closed position.

42. The apparatus of claim 40 wherein the rotor comprises a plurality of blades configured as at least one propeller.

43. The apparatus of claim 42 wherein the rotor comprises a plurality of coaxial propellers.