Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
First Claim
1. An apparatus for dilating and delivering a medicament to an obstruction within a vascular segment or a body passageway which comprises:
- a catheter having a distal end and a proximal end;
a substantially cylindrical shaped expansion member located on said distal end of said catheter, said expansion member having a first end and a second end, said first end being a distance from said second end;
an altering means engagable to said first end and said second end of said expansion member for altering said first distance therebetween to move said expansion member between a first configuration wherein said expansion member is characterized by a first diameter and a second configuration wherein said expansion member is characterized by a second diameter, said second diameter being greater than said first diameter; and
a therapeutic agent or medicament incorporated within a liposome coated on at least a portion of said expansion member.
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0 Petitions
Accused Products
Abstract
A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a liposome or micelle-encapsulated therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A liposome or micelle-encapsulated therapeutic agent or medicament is coated on either the expansion member, or incorporated into a substrate coated on the expansion member.
The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a liposome or micelle-encapsulated therapeutic agent or medicament to the obstruction.
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Citations
27 Claims
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1. An apparatus for dilating and delivering a medicament to an obstruction within a vascular segment or a body passageway which comprises:
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a catheter having a distal end and a proximal end;
a substantially cylindrical shaped expansion member located on said distal end of said catheter, said expansion member having a first end and a second end, said first end being a distance from said second end;
an altering means engagable to said first end and said second end of said expansion member for altering said first distance therebetween to move said expansion member between a first configuration wherein said expansion member is characterized by a first diameter and a second configuration wherein said expansion member is characterized by a second diameter, said second diameter being greater than said first diameter; and
a therapeutic agent or medicament incorporated within a liposome coated on at least a portion of said expansion member. - View Dependent Claims (10, 24, 26, 27)
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2. An apparatus for dilating and introducing molecules into cells within a vascular segment or a body passageway which comprises:
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a catheter having a distal end and a proximal end;
a substantially cylindrical shaped expansion member located on said distal end of said catheter, said expansion member having a first end and a second end, said first end being a distance from said second end;
an altering means engagable to said first end and said second end of said expansion member for altering said first distance therebetween to move said expansion member between a first configuration wherein said expansion member is characterized by a first diameter and a second configuration wherein said expansion member is characterized by a second diameter, said second diameter being greater than said first diameter; and
a lipsosome encapsulated medicament coated on at least a portion of said expansion member. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 13, 14)
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11. A mechanical dilatation and medicament delivery device comprising:
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a catheter having a distal end and a proximal end, said catheter having one or more lumens;
an substantially cylindrically shaped expandable mesh positioned on said distal end adapted to dilate an obstruction in a vessel, said mesh having a first contracted diameter and a second expanded diameter, said second expanded diameter being larger than said first contracted diameter; and
said mechanical dilatation and medicament delivery device being adapted to dilate said obstruction and expose said obstruction to a liposome medicament while allowing blood or bodily fluids to flow through said substantially cylindrically shaped expandable mesh.
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15. An apparatus for dilating and delivering a medicament to an obstruction within a vascular segment or a body passageway which comprises:
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a catheter having a distal end and a proximal end;
a substantially cylindrical shaped expansion member located on said distal end of said catheter, said expansion member having a first end and a second end, said first end being a distance from said second end;
an altering means engagable to said first end and said second end of said expansion member for altering said first distance therebetween to move said expansion member between a first configuration wherein said expansion member is characterized by a first diameter and a second configuration wherein said expansion member is characterized by a second diameter, said second diameter being greater than said first diameter; and
a therapeutic agent or medicament incorporated within a micelle and coated on at least a portion of said expansion member.
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16. An apparatus for dilating and introducing molecules into cells within a vascular segment or a body passageway which comprises:
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a catheter having a distal end and a proximal end;
a substantially cylindrical shaped expansion member located on said distal end of said catheter, said expansion member having a first end and a second end, said first end being a distance from said second end;
an altering means engagable to said first end and said second end of said expansion member for altering said first distance therebetween to move said expansion member between a first configuration wherein said expansion member is characterized by a first diameter and a second configuration wherein said expansion member is characterized by a second diameter, said second diameter being greater than said first diameter; and
a or micelle encapsulated medicament coated on at least a portion of said expansion member. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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25. A mechanical dilatation and medicament delivery device 2omprising:
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a catheter having a distal end and a proximal end, said catheter having one or more lumens;
an substantially cylindrically shaped expandable mesh positioned on said distal end adapted to dilate an obstruction in a vessel, said mesh having a first contracted diameter and a second expanded diameter, said second expanded diameter being larger than said first contracted diameter; and
said mechanical dilatation and medicament delivery device being adapted to dilate said obstruction and expose said obstruction to a micelle medicament while allowing blood or bodily fluids to flow through said expandable mesh.
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Specification