Creation of a database of biochemical data and methods of use
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Abstract
This invention is based on the observation that all diseases may be diagnosed by analysis of at least about 200-300 biochemicals present in a patient'"'"'s blood. In addition, disease progression may also be predicted from the profile of biochemicals in the blood. This invention takes advantage of rapid automated methods for determining the concentrations of biochemicals in the blood of a patient and compares these concentrations to a database which includes information derived from a multi-year study of approximately 200,000 persons. From the correlations found between biochemical concentrations in the blood and the existence of disease states, this invention permits the diagnosis of a present disease state in the patient and has the capacity to predict the emergence of future disease states in the patient.
33 Citations
38 Claims
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1-7. -7. (Canceled)
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8. A method of assessing a subject'"'"'s health or medical condition comprising:
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(a) providing one or more test samples obtained from a subject;
(b) exposing the one or more test samples to a Multi-Analyte Profile (MAP) Test 25 Panel comprising 20 or more subsets of microspheres, the microspheres of one subset being distinguishable from those of another subset and harboring at least one reagent designed to interact selectively, if not specifically, with a predetermined analyte, which interaction generates biochemical data concerning the predetermined analyte;
(c) gathering the biochemical data, if any, generated from the exposure;
(d) comparing the biochemical data generated from the one or more samples obtained from the subject with accumulated biochemical data generated from test samples taken periodically from at least about 1,000 individuals over a given time interval, which accumulated biochemical data provide a relationship between one or more predetermined analytes and the health or medical condition of a plurality of individuals whose accumulated biochemical data share similar features; and
(e) assessing the health or medical condition of the subject based, at least in part, on the results of the comparison. - View Dependent Claims (9, 10)
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11. A method of creating a database containing biochemical data from at least about 1,000 subjects, comprising:
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(a) providing one or more test samples obtained from one or more subjects;
(b) exposing a Multi-Analyte Profile (MAP) Test Panel to at least a portion of the one or more test samples to provide one or more test mixtures, the MAP Test Panel comprising 20 or more subsets of microspheres, the microspheres of one subset being distinguishable from those of another subset and harboring at least one reagent designed to interact selectively, if not specifically, with, and to generate biochemical data concerning, a predetermined analyte;
(c) optionally, adding one or more supplemental reagents to the one or more test mixtures to further the generation of the biochemical data;
(d) passing the exposed microspheres of the one or more test mixtures through a flow 20 analyzer to extract the biochemical data generated;
(e) compiling the biochemical data into a database, which permits retrieval of the biochemical data at least according to the identities or medical histories of the one or more subjects from which the one or more test samples were obtained; and
(f) repeating some or all of the foregoing steps until biochemical data from at least 25 about 1,000 subjects are compiled into the database. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification