Inorganic nanopartices to modify the viscosity and physical properties of ophthalmic and otic compositions

• US 20050002970A1
• Filed: 12/20/2002
• Published: 01/06/2005
• Est. Priority Date: 12/21/2001
• Status: Abandoned Application

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Incorporated
• Inventors: Ketelson, Howard Allen, Meadows, David L
• Application Number:
  US10/494,710
• Publication Number:
  US 20050002970A1
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/04 Artificial tears; Irrigation solutions
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics

Abstract

The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical nanoparticles are utilized to modify the rheological properties of the compositions, so as to enhance the viscosity, flow characteristics, lubricity or other characteristics of the compositions. The invention is particularly directed to the provision of lubricant compositions for the eye and ear, and to enhancement of the viscosity, shear thinning and lubricity of artificial tear compositions.

Claims

1. Use of inorganic nanoparticles to modify the viscosity or other physical properties of an ophthalmic or otic pharmaceutical composition.

2. A method of lubricating an eye or ear, which comprises applying an ophthalmic composition containing a lubricating effective amount of inorganic nanoparticles to the eye or ear

3. An ophthalmic or otic pharmaceutical composition, comprising an amount of inorganic nanoparticles sufficient to modify the viscosity or other physical properties of the composition.

4. A composition according to claim 3 wherein the nanoparticles have:

(a) particle dimensions less than 100 nm, but greater than 1 nm;

(b) surface areas ranging from 30 to 1000 m²/g; and

(c) an overall negative surface charge at a pH in the range of 6.0 to 7.8.

5. A composition according to claim 3, wherein the composition has a viscosity of 0.1 mPa*s to 10,000 mPa*s at a shear rate of 20 s⁻

1 to 0.01 s<sup>−

1</sup>.

6. A composition according to claims 3, 4 or 5, wherein the nanoparticles are formed from a synthetic clay material.

7. A composition according to claim 6, wherein the synthetic clay material comprises a smectite clay.

8. A composition according to claims 3, 4 or 5, wherein the nanoparticles are selected from the group consisting of zeolites, hydrotalcite, silica, aluminum oxide, cerium oxide, titanium oxide and zinc oxide.

9. A composition according to claims 3, 4 or 5, wherein the composition is a solution.

10. A composition according to claims 3, 4 or 5, wherein the composition is a thixotropic gel.