Method of sterilization of polymeric microparticles
First Claim
1. A sterilized polymeric material for use in a body of a mammal wherein said polymeric material is sterilized by irradiation at a temperature below 25°
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Abstract
This invention relates to the sterilization of polymeric material by irradiation for use in a body of a mammal. We have surprisingly discovered that the sterilization of polymeric materials for use in a mammal by irradiation is improved by reducing the temperature at which the irradiation is carried out. One aspect of this invention relates to a sterilized polymeric material for use in a body of a mammal wherein said polymeric material is sterilized by irradiation at a reduced temperature Another aspect of this invention relates to methods of sustained delivery of a therapeutically active agent to a mammal by using a polymeric material that has been sterilized at a reduced temperature by irradiation.
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Citations
39 Claims
- 1. A sterilized polymeric material for use in a body of a mammal wherein said polymeric material is sterilized by irradiation at a temperature below 25°
- 16. A method of sustained delivery of a therapeutically active agent to a mammal comprising administering a sterilized polymeric material comprising said therapeutically active agent to said mammal, wherein the polymeric material is sterilized by irradiation at a temperature below 25°
- 22. A method of sterilizing a polymeric material for use in a body of a mammal comprising irradiating said polymeric material at a temperature below 25°
- 27. A composition comprising sterilized polymeric microparticles and a therapeutically active agent for use in a body of a mammal wherein said polymeric material is sterilized by irradiation with external cooling of said polymeric material during sterilization.
- 32. A method of sterilizing a polymeric material for use in a body of a mammal comprising irradiating said polymeric material with external cooling of the polymeric material.
Specification