Thermolytic synthesis of inorganic oxides imprinted with functional moieties
First Claim
1. A process for producing an inorganic oxide imprinted with a plurality of functional groups, comprising:
- (a) contacting the inorganic oxide or a source thereof with an imprinting compound comprising (i) a plurality of functional moieties to be imprinted, (ii) a plurality of thermally labile protecting groups and (iii) a silicon- or germanium-containing moiety capable of serving as a linker for the imprinting compound to the inorganic oxide to form an inorganic oxide structure comprising immobilized imprinting compound; and
(b) removing a thermally labile portion of the imprinting compound from the oxide structure by thermolysis
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Abstract
Inorganic oxides, particularly silica or germania or inorganic oxides containing silica and/or germania, are imprinted with one or a plurality of functional moieties such as amine and/or thiol groups by a process featuring incorporating such groups into the oxide by use of a thermally labile material containing a protecting group for the amine or thiol, followed by removal of the thermally labile moiety by thermolysis. The resulting products are inorganic oxide substrates or bulk inorganic oxides imprinted with the functional moieties. A plurality of such moieties may be imprinted on a substrate in an order fashion using a polymeric imprinting compound, and may then be used as a templated array of functional moieties to which ordered metallic nanostructures may be constructed.
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Citations
61 Claims
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1. A process for producing an inorganic oxide imprinted with a plurality of functional groups, comprising:
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(a) contacting the inorganic oxide or a source thereof with an imprinting compound comprising (i) a plurality of functional moieties to be imprinted, (ii) a plurality of thermally labile protecting groups and (iii) a silicon- or germanium-containing moiety capable of serving as a linker for the imprinting compound to the inorganic oxide to form an inorganic oxide structure comprising immobilized imprinting compound; and
(b) removing a thermally labile portion of the imprinting compound from the oxide structure by thermolysis - View Dependent Claims (5, 6, 7, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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2. A process for producing an inorganic oxide imprinted with a functional group, comprising:
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(a) contacting the inorganic oxide or a source thereof with an imprinting compound comprising (i) a functional moiety to be imprinted, (ii) a thermally labile protecting group and (iii) a silicon- or germanium-containing moiety capable of serving as a linker for the imprinting compound to the inorganic oxide to form an inorganic oxide structure comprising immobilized imprinting compound; and
(b) removing a thermally labile portion of the imprinting compound from the oxide structure by thermolysis;
provided that if the oxide structure is an oxide substrate imprinted with a single functional group, then the imprinted group is other than isocyanate and the thermally labile protecting group is other than a carbamate of an aryl alcohol.
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3. A process for producing a bulk imprinted inorganic oxide imprinted with one or a plurality of functional groups, comprising:
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(a) copolymerizing a source of the organic oxide with an imprinting compound comprising (i) one or a plurality of functional moieties to be imprinted, (ii) one or a plurality of thermally labile protecting groups, and (iii) a silicon- or germanium-containing moiety capable of serving as a linker for the imprinting compound to the inorganic oxide to form an inorganic oxide structure comprising immobilized imprinting compound; and
(b) removing a thermally labile portion of the immobilized imprinting compound from the oxide structure by thermolysis.
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4. A process for producing an inorganic oxide substrate imprinted with one or a plurality of functional groups, comprising:
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(a) contacting a substrate comprising the inorganic oxide with an imprinting compound comprising (i) one or a plurality of functional moieties to be imprinted, (ii) one or a plurality of thermally labile protecting groups for the functional moieties, and (iii) a silicon- or germanium-containing moiety capable of serving as a linker for the imprinting compound to the inorganic oxide to form an inorganic oxide structure comprising immobilized imprinting compound; and
(b) removing a thermally labile portion of the imprinting compound by means of thermolysis;
provided that if the oxide structure is an oxide substrate imprinted with a single functional group, then the imprinted group is other than isocyanate and the thermally labile protecting group is other than a carbamate of an aryl alcohol moiety. - View Dependent Claims (9, 10)
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34. An inorganic oxide substrate comprising four or more thermolytically imprintable functional moieties;
- said functional moieties organized in a non-random pattern on the substrate.
- View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42)
- 43. An inorganic oxide substrate imprinted with a plurality of functional moieties selected from amine, thiol, isocyanate, carboxyl, hydroxyl, phenoxyl, phosphate and titanate.
- 56. A hydrophilic bulk inorganic oxide imprinted with one or more isolated functional moieties selected from amine, thiol, isocyanate, carboxyl, hydroxyl, phenoxyl, phosphate and titanate.
- 60. A hydrophilic bulk inorganic oxide imprinted with one or more amine or thiol functional moieties, further comprising a catalytically active metal, and having substantially no capping of free hydroxyl groups.
Specification