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Single molecule detection with surface-enhanced raman scattering and applications in DNA or RNA sequencing

  • US 20050003376A1
  • Filed: 11/26/2003
  • Published: 01/06/2005
  • Est. Priority Date: 02/27/1998
  • Status: Abandoned Application
First Claim
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1. A method for determining the presence of at least one analyte, comprising:

  • providing a sample comprising a plurality of aggregates of size of at least about 500 nm adsorbing a plurality of analytes;

    exposing the sample to electromagnetic radiation to cause surface-enhanced emission;

    obtaining spectral information of the sample, wherein at least one spectral line of the information represents a single analyte adsorbed on one of the plurality of aggregates; and

    determining the presence of the single analyte from the at least one spectral line.

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