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Libraries of oligomers labeled with different tags

  • US 20050003408A1
  • Filed: 05/11/2004
  • Published: 01/06/2005
  • Est. Priority Date: 05/15/1998
  • Status: Active Grant
First Claim
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1. A method of making a set of labelled compounds, by the use of a support and a set of labels, said method comprising the steps of:

  • a) at least one first or intermediate step comprising dividing the support into lots, performing a different chemical reaction on each lot of the support so as either to modify that lot of the support or to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support, and b) at least one intermediate or final step comprising dividing the support into lots, performing a different chemical reaction on each lot of the support, so as either to modify that lot of the support or to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different cleavable label, whereby each different cleavable label is linked to a chemical moiety coupled to the support in a different step and forms with that chemical moiety a labelled compound which is separable from the support, and combining the said lots of the support.

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