Modulators of VR1 receptor
First Claim
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1. A method for modulating VR1, comprising the step of contacting said VR1 with a compound of formula I:
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Abstract
The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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Citations
18 Claims
- 1. A method for modulating VR1, comprising the step of contacting said VR1 with a compound of formula I:
- 6. A compound having formula II:
- 8. A compound having formula:
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18. A method of treating or lessening the severity of a disease in a patient selected from for treating or lessening the severity of one or more of the following conditions, inflammatory pain, neuropathic pain, acute pain, chronic pain, post-operative pain, migraine, arthralgia, nerve injury, neurodegeneration, neuropathies, diabetic neuropathy, hyperactive urinary bladder, hypersensitive urinary bladder, urinary incontinence, interstitial cystitis, painful bladder disorders, irritable bowel syndrome, inflammatory bowel disease, inflammatory disease, asthma, chronic obstructive pulmonary disease, digestive tract ulcer, skin irritation, or eye irritation, mucous membrane irritation, comprising the step of administering to said patient a compound of formula (I), formula (II), or formula (III).
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