Backflow prevention for high pressure gradient systems
First Claim
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1. A method for improving the compositional accuracy of high pressure gradient pumps for high pressure liquid chromatography comprising the steps of:
- providing a first solvent line having a first set of pumps and a second solvent line having a second set of pumps said first set of pumps being in fluid communication with to a first solvent reservoir and said second set of pumps being in fluid communication with a second solvent reservoir;
connecting said first set of pumps to a first pulse dampener and connecting said second set of pumps to a second pulse dampener said first pulse dampener being in fluid communication with a first backflow preventor and said second pulse dampener being in fluid communication with a second blackflow preventor wherein said backflow preventors substantially reduce fluidic cross talk between said solvent lines;
connecting said backflow preventors to a mixing tee to deliver solvent composition.
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Abstract
Gradient performance with high pressure gradient solvent delivery system is optimized by approximation of infinite stroke volume of high pressure pumps by the addition of pulse dampening with backflow prevention to each high pressure pump. The backflow prevention adds sufficient minimum flow resistance, thereby enhancing the performance of the pulse dampening over a wider range of flow rates resulting in consistent gradient performance.
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Citations
22 Claims
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1. A method for improving the compositional accuracy of high pressure gradient pumps for high pressure liquid chromatography comprising the steps of:
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providing a first solvent line having a first set of pumps and a second solvent line having a second set of pumps said first set of pumps being in fluid communication with to a first solvent reservoir and said second set of pumps being in fluid communication with a second solvent reservoir;
connecting said first set of pumps to a first pulse dampener and connecting said second set of pumps to a second pulse dampener said first pulse dampener being in fluid communication with a first backflow preventor and said second pulse dampener being in fluid communication with a second blackflow preventor wherein said backflow preventors substantially reduce fluidic cross talk between said solvent lines;
connecting said backflow preventors to a mixing tee to deliver solvent composition. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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18. A high pressure liquid chromatography apparatus comprising:
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a mixing tee having an outlet port, a first inlet port and a second inlet port; and
a backflow preventor incorporated within said first and second inlet port said backflow preventors having a selected coil spring and an actuator seated within a valve seat wherein said selected coil spring exerts a selected pressure upon said actuator. - View Dependent Claims (19, 20, 21)
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22. A high pressure liquid chromatography apparatus comprising:
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a mixing tee having an outlet port, a first inlet port and a second inlet port; and
a backflow preventor incorporated within said first and second inlet port said backflow preventors having a ball bearing seated within a valve seat wherein said ball bearing limits fluid flow to a forward direction.
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Specification