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Backflow prevention for high pressure gradient systems

  • US 20050008516A1
  • Filed: 08/04/2004
  • Published: 01/13/2005
  • Est. Priority Date: 12/09/2002
  • Status: Active Grant
First Claim
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1. A method for improving the compositional accuracy of high pressure gradient pumps for high pressure liquid chromatography comprising the steps of:

  • providing a first solvent line having a first set of pumps and a second solvent line having a second set of pumps said first set of pumps being in fluid communication with to a first solvent reservoir and said second set of pumps being in fluid communication with a second solvent reservoir;

    connecting said first set of pumps to a first pulse dampener and connecting said second set of pumps to a second pulse dampener said first pulse dampener being in fluid communication with a first backflow preventor and said second pulse dampener being in fluid communication with a second blackflow preventor wherein said backflow preventors substantially reduce fluidic cross talk between said solvent lines;

    connecting said backflow preventors to a mixing tee to deliver solvent composition.

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