Protein arrays for high-throughput screening
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Abstract
Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.
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Citations
81 Claims
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1-41. -41. (canceled)
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42. An array of proteins, comprising:
- a substrate; and
a plurality of patches arranged in discrete known regions on said substrate, wherein each of said patches comprises an immobilized protein, and wherein the array comprises 100 or more patches per 1 cm2. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
- a substrate; and
Specification