Biosensor
First Claim
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1. A biosensor comprising a substrate coated with a hydrophobic polymer.
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Abstract
It is an object of the present invention to provide a detection surface used for a biosensor wherein nonspecific adsorption is repressed. The present invention provides a biosensor comprising a substrate coated with a hydrophobic polymer.
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Citations
40 Claims
- 1. A biosensor comprising a substrate coated with a hydrophobic polymer.
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6. A biosensor comprising a substrate coated with a film whose swelling degree in pure water at 25°
- C. is between 1 and 5 with respect to the film thickness in a dry state.
- View Dependent Claims (7, 8, 9, 10, 11)
- 30. A method for detecting or measuring a substance interacting with a physiologically active substance which is bound to the surface of a biosensor comprising a substrate coated with a hydrophobic polymer, wherein the above detection or measurement is carried out in the presence of a surfactant.
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34. A measurement chip used for a surface plasmon resonance measurement device comprising:
- a dielectric block;
a metal film formed on a face of the dielectric block;
a light source for generating a light beam;
an optical system for allowing said light beam to enter said dielectric block such that total reflection conditions can be obtained at the interface between said dielectric block and said metal film and that components at various incident angles can be contained; and
a light-detecting means for detecting the state of surface plasmon resonance by measuring the intensity of the light beam totally reflected at said interface,said measurement chip being comprised of said dielectric block and said metal film, wherein said dielectric block is formed as one block comprising the entirety of the entrance face and exit face of said light beam and a face on which said metal film is formed, said metal film is integrated with the dielectric block, and said metal film is coated with a hydrophobic polymer. - View Dependent Claims (35, 36, 37, 38, 39, 40)
- a dielectric block;
Specification