Composition of matter comprising library of first nucleic acid analyte copies
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Abstract
This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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Citations
252 Claims
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1-211. -211. (CANCELED).
- 212. A composition of matter comprising a library of first nucleic acid copies, said first nucleic acid copies being hybridized to an array of nucleic acids, said nucleic acids being fixed or immobilized to a solid support, wherein said first nucleic acid copies comprise an inherent universal detection target (UDT) and a universal detection element (UDE) attached to said UDT, wherein said UDE generates a signal directly or indirectly to detect the presence or quantity of said analytes.
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232. A composition of matter comprising a library of first nucleic acid copies, said first nucleic acid copies being hybridized to an array of nucleic acids, said nucleic acids being fixed or immobilized to a solid support, wherein said first nucleic acid copies comprise one or more non-inherent universal detection targets (UDTs) and one or more universal detection elements (UDEs) attached to said UDTs, wherein said UDEs generate a signal directly or indirectly to detect the presence or quantity of said analytes, and wherein said UDTs are either:
- (i) at the 5′
ends of said first nucleic acid copies and not adjacent to an oligoT segment or sequence, or (ii) at the 3′
ends of said first nucleic acid copies, or (iii) both (i) and (ii). - View Dependent Claims (233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251)
- (i) at the 5′
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252-952. -952. (CANCELED)
Specification