Polymer derivatives having particular atom arrangements
7 Assignments
0 Petitions
Accused Products
Abstract
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
105 Citations
49 Claims
- 1. A polymeric reagent comprising a
-
26. A method of preparing a polymeric reagent comprising the steps of
(i) providing a precursor molecule optionally comprised of a protected reactive group and one or more hydroxyl groups; -
(ii) activating at least one of the one or more hydroxyl groups of the precursor molecule for reaction with an amino group to form an activated precursor molecule;
(iii) contacting under covalent coupling conditions at least one of the one or more activated hydroxyl groups with a water-soluble polymer having a amino group, thereby forming a polymer comprised of the water-soluble polymer portion and the protected reactive group; and
(iv) deprotecting the protected reactive group, when present, thereby forming the polymeric reagent. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
-
- 39. A conjugate comprising a water-soluble polymer, a
-
49. A polymer comprising a water-soluble polymer, a
Specification