Choice of wavelengths for multiwavelength optical imaging
First Claim
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1. A method of optical imaging of turbid media using a plurality of discrete wavelengths in an optical imaging system, the method comprising the steps of:
- selecting a set of chromophores for characterizing a property of the turbid media;
defining parameters of the system including at least a number of said discrete wavelengths, a value of each of said wavelengths, source power and detector aperture for each of said wavelengths, a choice of image algorithm and source/detector geometries, a choice of source and detector and noise characteristics;
fixing a value of all of said parameters except a plurality of said parameters values to be optimized;
determining an optimal value for each of said parameter values to be optimized as a function of a performance of the system in measuring a concentration of said chromophores in said turbid media for characterizing said property as a whole; and
using said optimal value for each of said parameter values in imaging said turbid media.
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Abstract
The present invention relates to a method for wavelength selection in a multi-wavelength TPSF or CW-based optical imaging system. This consists of identifying several chromophores in a highly turbid medium and selecting optimized wavelengths whereby using these wavelengths optimizes the deduction of the chromophore concentrations. Such chromophore concentrations may be combined to deduce other properties of the turbid medium.
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Citations
22 Claims
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1. A method of optical imaging of turbid media using a plurality of discrete wavelengths in an optical imaging system, the method comprising the steps of:
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selecting a set of chromophores for characterizing a property of the turbid media;
defining parameters of the system including at least a number of said discrete wavelengths, a value of each of said wavelengths, source power and detector aperture for each of said wavelengths, a choice of image algorithm and source/detector geometries, a choice of source and detector and noise characteristics;
fixing a value of all of said parameters except a plurality of said parameters values to be optimized;
determining an optimal value for each of said parameter values to be optimized as a function of a performance of the system in measuring a concentration of said chromophores in said turbid media for characterizing said property as a whole; and
using said optimal value for each of said parameter values in imaging said turbid media. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification