Novel methods for administration of drugs and devices useful thereof
First Claim
1. A method for administration of a substance into a subject'"'"'s skin, comprising delivering the substance into a junctional layer of the subject'"'"'s skin.
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Accused Products
Abstract
The present invention relates to methods for administration of a substance into the junctional layer of a subject'"'"'s skin, i.e., a transitory tissue between the reticular dermis and the hypodermis of the subcutaneous layer of the skin. The present invention provides an improved method of parenteral drug delivery in that it provides among other benefits, minimized unwanted immune response and inadvertent immunotoxic effects provoked by the substance administered. In addition, an improved pharmacokinetic profile can be obtained by employing the methods of the present invention. Devices that can be used in accordance with the methods of the invention are also disclosed.
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Citations
30 Claims
- 1. A method for administration of a substance into a subject'"'"'s skin, comprising delivering the substance into a junctional layer of the subject'"'"'s skin.
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22. A device for delivering a substance into a junctional layer of a subject comprising:
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(a) a needle having a length sufficient to penetrate the junctional layer and an outlet at a depth within the junctional layer so that the substance is delivered and distributed in the junctional layer;
(b) a structure for loading, storing and dispensing the substance; and
(c) a structure for controlling skin penetration to the desired depth within the junctional layer. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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Specification