Application of stimulus to white matter to induce a desired physiological response
First Claim
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1. A system for treating a condition in a brain of an animal, comprising:
- a delivery mechanism operative to deliver at least one stimulus to a white matter site in the brain that is associated with a non-white matter brain structure, such that delivery of the stimulus to the white matter site induces a physiological response in the associated non-white matter brain structure.
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Abstract
The present invention relates to providing a stimulus to brain structures having high fiber density, such as white matter tracts. The stimulus, which can be electrical, pharmacological and/or genetic, is operative to employ the white matter to affect associated brain structures associated with the white matter to help induce a desired physiological response, such as helping to reduce or control seizures.
115 Citations
37 Claims
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1. A system for treating a condition in a brain of an animal, comprising:
a delivery mechanism operative to deliver at least one stimulus to a white matter site in the brain that is associated with a non-white matter brain structure, such that delivery of the stimulus to the white matter site induces a physiological response in the associated non-white matter brain structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for changing a physiological condition of an animal, comprising:
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a delivery device operative to provide a stimulus to a region of white matter of the animal'"'"'s brain, the white matter region being connected with a non-white matter region of the animal'"'"'s brain via a pathway projecting into the region of white matter; and
the stimulus comprising a vector having genetic material engineered to induce expression of at least one therapeutic protein in target cells of the non-white matter region for providing a desired physiological response in the animal. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A system for treating a condition in a brain of an animal, comprising:
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means for locating at least one white matter site of the animal'"'"'s brain that is fibrously connected with a non-white matter region of the animals brain; and
means for applying a stimulus to the at least one white matter site of the animal'"'"'s brain to induce a corresponding physiological response in the non-white matter region. - View Dependent Claims (24)
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25. A method comprising:
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placing a delivery device in communication with a white matter brain structure that is associated with at least one predetermined non-white matter brain structure; and
using the delivery device to provide a stimulus to the white matter brain structure to induce a desired physiological response in the non-white matter brain structure associated therewith. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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Specification