Method of skin care using lipoic and ascorbic acids

• US 20050013783A1
• Filed: 06/21/2004
• Published: 01/20/2005
• Est. Priority Date: 09/20/1995
• Status: Active Grant

• Current Assignee: NV Perricone LLC
• Original Assignee: NV Perricone LLC
• Inventors: Perricone, Nicholas V.
• Granted Patent: US 7,438,896 B2
• Time in Patent Office: Days
• US Class Current: 424/59
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 8/4986 with sulfur as the only hetero atom
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/004 Aftersun preparations

Abstract

Methods for the prevention of skin damage arising from exposure to ultraviolet or solar radiation, using lipoic acid and asorbic acid and/or ascorbic acid derivative in a dermatologically acceptable carrier that can be topically applied to the skin areas. Tocotrienol and/or an α-hydroxy acid such as glycolic acid is applied with the lipoic acid and ascorbic acid an/or its derivatives in some embodiments.

Claims

1. A method for the prevention of erythema induced by exposure to ultraviolet or solar radiation, comprising:

applying a composition containing lipoic acid and ascorbic acid and/or ascorbic acid derivatives in a dermatologically acceptable carrier to exposed skin tissue.

3. A method in accordance with claims 1 or 2, wherein said lipoic acid is about 0.1% to about 5.0% by weight of said composition.

4. A method in accordance with claim 3, wherein said lipoic acid is about 0.25% to about 3.0% by weight of said composition.

5. A method in accordance with claim 4, wherein said lipoic acid is about 0.5% to about 1.5% by weight of said composition.

6. A method in accordance with claims 1 or 2, wherein an amount of said ascorbic acid and/or ascorbic acid derivatives is about 0.1% to about 5.0% by weight.

7. A method in accordance with claim 6, wherein an amount of said ascorbic acid and/or ascorbic acid derivatives is about 0.5%-1.5% by weight of said composition.

8. A method in accordance with claim 1 or 2, wherein said ascorbic acid derivatives comprise fat-soluble fatty acid esters of ascorbic acid.

9. A method in accordance with claim 8, wherein said fat-soluble fatty acid esters of ascorbic acid consist of ascorbyl palmitate.

10. A method in accordance with claims 1 or 2, wherein said composition further comprises one or more additional ingredients selected from the group consisting of:

tocotrienols and tocotrienaol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives; and

α

-hydroxy acids.

11. A method in accordance with claim 10, wherein said α

-hydroxy acid comprises glycolic acid or lactic acid.

12. A method in accordance with claim 10 wherein an amount of said α

-hydroxy acid is about 0.1% to about 5.0% by weight of said composition.

13. A method in accordance with claim 10 wherein an amount of said tocotrienols and tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives is about 0.1% to about 5.0% by weight of said composition.

14. A method in accordance with claim 10 wherein said lipoic acid is about 0.1% to about 5.0% by weight of said composition.

15. A method in accordance with claim 13, wherein said lipoic acid is about 0.25% to about 3.0% by weight of said composition.

2. A method for the prevention of skin damage induced by exposure to ultraviolet or solar radiation, comprising:

applying a composition containing lipoic acid and ascorbic acid and/or ascorbic acid derivatives in a dermatologically acceptable carrier to exposed skin tissue.

16. A dermatological composition for preventing sunburn and skin damage, and for treating sunburn or sunburn skin damage, comprising:

an effective amount of lipoic acid, and

an effective amount of one or more ingredients selected from the group consisting of;

ascorbic acid and ascorbic acid derivatives; and

α

-hydroxy acids.

17. A composition according to claim 16 comprising from about 0.1% to about 5% lipoic acid.

18. A composition according to claim 17 comprising from about 0.25% to about 5% lipoic acid.

19. A method in accordance with claim 16, wherein an amount of said ascorbic acid and/or ascorbic acid derivatives is about 0.1% to about 5.0% by weight of said composition.

20. A method in accordance with claim 19, wherein an amount of said ascorbic acid and/or ascorbic acid derivatives is about 0.25%-0.5% by weight of said composition.