Antimicrobial medical devices
First Claim
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1. A method for making an antimicrobial medical device, comprising the steps of:
- obtaining a polymerizable fluid composition comprising a siloxane-containing macromer and a vinylic monomer capable of reducing silver cations;
forming a polymerizable dispersion comprising silver nanoparticles and having a stability of at least about 60 minutes, wherein the silver nanoparticles are formed by adding a desired amount of a soluble silver salt into the fluid composition;
introducing an amount of the polymerizable dispersion in a mold for making a medical device; and
polymerizing the polymerizable dispersion in the mold to form the antimicrobial medical device containing silver nanoparticles.
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Abstract
The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
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Citations
43 Claims
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1. A method for making an antimicrobial medical device, comprising the steps of:
- obtaining a polymerizable fluid composition comprising a siloxane-containing macromer and a vinylic monomer capable of reducing silver cations;
forming a polymerizable dispersion comprising silver nanoparticles and having a stability of at least about 60 minutes, wherein the silver nanoparticles are formed by adding a desired amount of a soluble silver salt into the fluid composition;
introducing an amount of the polymerizable dispersion in a mold for making a medical device; and
polymerizing the polymerizable dispersion in the mold to form the antimicrobial medical device containing silver nanoparticles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- obtaining a polymerizable fluid composition comprising a siloxane-containing macromer and a vinylic monomer capable of reducing silver cations;
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14. A method for making an antimicrobial medical device, comprising the steps of:
- obtaining a polymerizable fluid composition comprising a siloxane-containing macromer and a soluble silver salt;
forming a polymerizable dispersion comprising silver nanoparticles and having a stability of at least about 60 minutes, wherein the silver nanoparticles are formed by adding into the fluid composition at least one biocompatible reducing agent;
introducing an amount of the polymerizable dispersion in a mold for making a medical device; and
polymerizing the polymerizable dispersion in the mold to form the antimicrobial medical device containing silver nanoparticles. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
- obtaining a polymerizable fluid composition comprising a siloxane-containing macromer and a soluble silver salt;
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24. A method for making an antimicrobial medical device, comprising the steps of:
- obtaining a stabilized-silver nano-particle solution or lyophilized stabilized-silver nano-particles;
directly dispersing a desired amount of the stabilized-silver nano-particle solution or the lyophilized stabilized-silver nano-particles in a polymerizable fluid composition comprising a siloxane-containing macromer to form a polymerizable dispersion having a stability of at least about 60 minutes;
introducing an amount of the polymerizable dispersion in a mold for making a medical device; and
polymerizing the polymerizable dispersion in the mold to form the antimicrobial medical device containing silver nanoparticles. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
- obtaining a stabilized-silver nano-particle solution or lyophilized stabilized-silver nano-particles;
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33. An antimicrobial ophthalmic device, comprising:
- a polymer matrix, silver-nanoparticles distributed therein and at least one dye and/or pigment distributed therein in a substantially uniform amnner, wherein the polymer matrix includes a polysiloxane unit, has a high oxygen permeability characterized by a Dk greater than 60 barrers and a high ion permeability characterized by an ionoflux diffusion coefficient of great than 6.0×
10−
4 mm2/min, and comprises a water content of at least 15 weight percent when fully hydrated, wherein the antimicrobial medical device exhibit at least a 5-fold reduction (≧
80% inhibition) of viable microorganisms, and wherein the dye and/or pigment, in combination with the color of the silver nano-particle, provides a desired color. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
- a polymer matrix, silver-nanoparticles distributed therein and at least one dye and/or pigment distributed therein in a substantially uniform amnner, wherein the polymer matrix includes a polysiloxane unit, has a high oxygen permeability characterized by a Dk greater than 60 barrers and a high ion permeability characterized by an ionoflux diffusion coefficient of great than 6.0×
Specification