System and method for control of a subject's circadian cycle
First Claim
1. A method for controllably adjusting a circadian cycle of a subject to track a reference trajectory, the method comprising:
- providing at least one model representative of a response of a circadian state of the subject to a stimulus control signal; and
generating an optimal stimulus control signal using model predictive control based on the model, wherein generating the optimal stimulus control signal comprises minimizing a cost function which comprises a cost term which is a function of a tracking error and wherein minimizing the cost function is subject to constraints which comprise minimum and maximum stimulus control signal levels.
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Abstract
Aspects of the invention provide systems and methods for controllably adjusting the circadian pacemaker cycle of a subject using light (or other stimulus) through application of model-based predictive control techniques. This approach allows the use of closed-loop feedback to compensate for modeling errors, unknown initial conditions and disturbances. It also allows an optimal level of light (or other stimulus) to be generated based on minimization of a cost function. The cost function may incorporate a term associated with tracking errors and a term associated with the amount of light used. The tracking function may be minimized subject to one or more constraints which may include a minimum and maximum amount of light (or other stimulus).
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Citations
49 Claims
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1. A method for controllably adjusting a circadian cycle of a subject to track a reference trajectory, the method comprising:
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providing at least one model representative of a response of a circadian state of the subject to a stimulus control signal; and
generating an optimal stimulus control signal using model predictive control based on the model, wherein generating the optimal stimulus control signal comprises minimizing a cost function which comprises a cost term which is a function of a tracking error and wherein minimizing the cost function is subject to constraints which comprise minimum and maximum stimulus control signal levels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for controllably adjusting a circadian cycle of a subject to track a reference trajectory, the method comprising:
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obtaining input information, the input information comprising a signal representative of the reference trajectory, a feedback signal representative of a circadian state of the subject and one or more stimulus level constraints;
predicting a free response of the circadian state of the subject starting at a current time and extending out to a first future time using a response predictor subject model representative of a response of the circadian state of the subject to a stimulus;
determining an optimal series of control moves starting at the current time and extending out to second future time using a controller subject model representative of a response of the circadian state of the subject to a stimulus, the optimal series of control moves based, at least in part, on the free response of the circadian state of the subject, the reference trajectory signal and the current circadian state feedback signal; and
outputting a stimulus control signal to one or more stimulus sources, the stimulus control signal comprising a current one of the series of control moves; and
applying the stimulus control signal to one or more stimulus sources to determine an intensity thereof. - View Dependent Claims (34, 35)
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36. A system for controllably adjusting a circadian cycle of a subject to track a reference trajectory, the system comprising:
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one or more inputs for receiving the reference trajectory and for receiving constraints which comprise minimum and maximum stimulus control signal levels;
a response predictor connected to receive a feedback signal representative of a circadian state of the subject, the response predictor configured to predict a free response of the circadian state of the subject starting at a current time and extending out to a first future time using a response predictor subject model representative of a response of the circadian state of the subject to a stimulus; and
a control sequence generator connected to receive the reference trajectory, the constraints, the feedback signal and the free response of the circadian state of the subject, the control sequence generator configured to determine an optimal series of control moves starting at the current time and extending out to a second future time using a controller subject model representative of a response of the circadian state of the subject to a stimulus, wherein the control sequence generator is connected to output a stimulus control signal to at least one stimulus source, the stimulus control signal comprising a current control move in the optimal series of control moves and the stimulus control signal determining an intensity of the at least one stimulus source. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43)
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44. A system for controllably adjusting a circadian cycle of a subject to track a reference trajectory, the system comprising:
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one or more inputs for receiving the reference trajectory and for receiving constraints which comprise minimum and maximum stimulus control signal levels;
means for predicting a free response of a circadian state of the subject starting at a current time and extending out to a first future time based, at least in part, on a feedback signal representative of the circadian state of the subject;
means for determining an optimal series of control moves starting at the current time and extending out to a second future time based, at least in part, on the reference trajectory, the constraints, the feedback signal and the free response of the circadian state of the subject; and
means for applying a stimulus control signal to at least one stimulus source, the stimulus control signal comprising at least a portion of the optimal series of control moves and the stimulus control signal determining an intensity of the at least one stimulus source.
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45. A method for altering a phase of a circadian cycle of a subject, the method comprising:
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providing a controller subject model representing a response of a circadian state of the subject to a stimulus;
receiving a reference circadian trajectory, the reference circadian trajectory phase shifted from a current circadian cycle of the subject;
determining a series of stimulus control moves predicted by the controller subject model to result in the circadian cycle of the subject changing so as to track the reference circadian trajectory;
applying at least a portion of the series of stimulus control moves to one or more stimulus sources, the one or more stimulus sources providing stimulus which is received by the subject;
wherein determining the series of stimulus control moves comprises applying an optimization process using the controller subject model. - View Dependent Claims (46, 47, 48, 49)
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Specification