Formulation of powder containing nanoparticles for aerosol delivery to the lungs
First Claim
1. A method of formulating a powder containing nanoparticles for aerosol delivery to the lung, the method comprising the steps of:
- mixing nanoparticles with a liquid carrier to create a mixture; and
forming the mixture into carrier particles having a size suitable for aerosol delivery to the lung.
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Accused Products
Abstract
Respirable particles carrying active principles or diagnostics in nanoparticle form are created by mixing the nanoparticles with liquid carrier, then forming the resultant mixture into respirable particles. Spray-drying, freeze spray drying and drying followed by comminution may be used to create the respirable particles, which may be delivered to the lung via a dry powder inhaler. In one example, lactose was used as the excipient and spray-dried with two different types of nanoparticle: gelatin and poly butylcyanoacrylate nanoparticles. The incorporation of nanoparticles did not affect the respirable fraction of the carrier powders.
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Citations
13 Claims
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1. A method of formulating a powder containing nanoparticles for aerosol delivery to the lung, the method comprising the steps of:
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mixing nanoparticles with a liquid carrier to create a mixture; and
forming the mixture into carrier particles having a size suitable for aerosol delivery to the lung. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification