Heterocyclic compounds as inhibitors of beta-lactamases
First Claim
1. A method for inhibiting bacterial β
- -lactamases in man or an animal comprising administering to said man or said animal a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, of formula (I);
5 Assignments
0 Petitions
Accused Products
Abstract
This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising administering a therapeutically effective amount to said man or said animal of a compound, or pharmaceutically acceptable salt thereof, of formula (I) either alone or in combination with a β-lactamine antibiotic wherein said combination can be administered separately, together or spaced out over time. Pharmaceutical compositions comprising a compound of formula (I), or a combination of a compound of formula (I) and a therapeutically effective amount of a β-lactamine antibiotic, and a pharmaceutically acceptable carrier are also disclosed and claimed.
87 Citations
18 Claims
-
1. A method for inhibiting bacterial β
- -lactamases in man or an animal comprising administering to said man or said animal a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, of formula (I);
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- -lactamases in man or an animal comprising administering to said man or said animal a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, of formula (I);
-
9. A method for the treatment of bacterial infection in man or an animal comprising inhibiting bacterial β
- -lactamases by administering to said man or said animal a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, of formula (I);
- View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
- -lactamases by administering to said man or said animal a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, of formula (I);
- 17. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, of formula (I):
Specification
-
- Resources
-
Current AssigneeAllergan Pharmaceuticals International Ltd. (Abbvie Incorporated)
-
Original AssigneeAventis Pharma SA (Sanofi )
-
InventorsFromentin, Claude, Aszodi, Jozsef, Rowlands, David Alan, Lampilas, Maxime
-
Granted Patent
-
Time in Patent OfficeDays
-
Field of Search
-
US Class Current514/214.30
-
CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/439 the ring forming part of a ...A61K 31/55 having seven-membered rings...A61P 31/00 Antiinfectives, i.e. antibi...A61P 31/04 Antibacterial agentsA61P 43/00 Drugs for specific purposes...Y02A 50/30 Against vector-borne diseas...
