Antimicrobial elastomer composition and method for making

• US 20050020844A1
• Filed: 08/19/2004
• Published: 01/27/2005
• Est. Priority Date: 04/11/2001
• Status: Active Grant

• Current Assignee: Freudenberg Medical, LLC (Freudenberg & Company KG)
• Original Assignee: Helix Medical LLC (Freudenberg & Company KG)
• Inventors: Nelson, Jesse N.
• Granted Patent: US 7,393,547 B2
• Time in Patent Office: Days
• US Class Current: 556/467
• CPC Class Codes: A61F 2/203 comprising an air passage from trachea to oesophagus or to pharynx; Artificial epiglottis
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08F 290/06 Polymers provided for in subclass C08G
• CPC Class Codes: C08G 77/04 Polysiloxanes
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A method for making an elastomeric material containing an antimicrobial composition such as a dispersion of silver oxide that is suitable for implantation within the body. The elastomer made in accordance with this method extends the amount of work-time available for processing the elastomer into an article as compared with the work-time available when using prior art compounding methods.

Claims

1. A method for making an antimicrobial elastomeric composition comprising the steps of:

(a) presenting Part A and Part B of a silicone elastomer wherein when Part A and Part B are mixed together in the presence of an initiator, a curable, injection-moldable silicone elastomer is formed;

(b) mixing part A with part B to form a injection-moldable silicone elastomer;

(c) dispersing additional inhibitor into the silicone elastomer wherein the inhibitor is any agent that increases the cure time of the silicone elastomer; and

(d) compounding an antimicrobial agent into the silicone elastomer.

2. The method for making an antimicrobial elastomeric composition in accordance with claim 1 wherein said antimicrobial agent is silver oxide.

3. The method for making an antimicrobial elastomeric composition in accordance with claim 1 wherein said inhibitor is 2-methyl-3-butyn-2-ol.

13. The method for making an antimicrobial elastomeric composition in accordance with claim 1 wherein said microbial agent is 5-50% w/w silver oxide and said additional inhibitor is 2-methyl-3-butyn-2-ol and wherein the mole ratio of additional inhibitor to silver oxide when Part A and Part B are mixed is about 1:

40.

4. A method for making an antimicrobial elastomeric composition comprising the steps of:

(a) presenting Part A and Part B of a silicone elastomer wherein when Part A and Part B are mixed together in the presence of an initiator, a curable, injection-moldable silicone elastomer is formed;

(b) adding additional inhibitor to either Part A or Part B;

(c) dispersing particles of an antimicrobial agent in either Part A or Part B; and

(d) mixing Part A with Part B.

5. The method for making an antimicrobial elastomeric composition in accordance with claim 4 wherein said inhibitor is 2-methyl-3-butyn-2-ol.

6. The method for making an antimicrobial elastomeric composition in accordance with claim 4 wherein said antimicrobial agent is silver oxide.

14. The method for making an antimicrobial elastomeric composition in accordance with claim 4 wherein said microbial agent is 5-50% w/w silver oxide and said additional inhibitor is 2-methyl-3-butyn-2-ol and wherein the mole ratio of additional inhibitor to silver oxide when Part A and Part B are mixed is about 1:

40.

7. A method for making an antimicrobial elastomeric composition comprising the steps of:

(a) presenting Part A and Part B of a silicone elastomer wherein when Part A and Part B are mixed together in the presence of an initiator, a curable, injection-moldable silicone elastomer is formed;

(b) adding additional inhibitor to both Part A and Part B;

(c) dispersing particles of an antimicrobial agent in Part A or Part B; and

(d) mixing Part A with Part B.

8. The method for making an antimicrobial elastomeric composition in accordance with claim 7 wherein said inhibitor is 2-methyl-3-butyn-2-ol.

9. The method for making an antimicrobial elastomeric composition in accordance with claim 7 wherein said antimicrobial agent is silver oxide.

15. The method for making an antimicrobial elastomeric composition in accordance with claim 7 wherein said microbial agent is 5-50% w/w silver oxide and said additional inhibitor is 2-methyl-3-butyn-2-ol and wherein the mole ratio of additional inhibitor to silver oxide when Part A and Part B are mixed is about 1:

40.

10. A method for making an antimicrobial elastomeric composition comprising the steps of:

(a) presenting Part A and Part B of a silicone elastomer wherein when Part A and Part B are mixed together in the presence of an initiator, a curable, injection-moldable silicone elastomer is formed;

(b) adding additional inhibitor to either Part A or Part B;

(c) dispersing particles of an antimicrobial agent in Part A and Part B; and

(d) mixing Part A with Part B.

11. The method for making an antimicrobial elastomeric composition in accordance with claim 10 wherein said antimicrobial agent is silver oxide.

12. The method for making an antimicrobial elastomeric composition in accordance with claim 10 wherein said inhibitor is 2-methyl-3-butyn-2-ol.

16. The method for making an antimicrobial elastomeric composition in accordance with claim 10 wherein said microbial agent is 5-50% w/w silver oxide and said additional inhibitor is 2-methyl-3-butyn-2-ol and wherein the mole ratio of additional inhibitor to silver oxide when Part A and Part B are mixed is about 1:

40.