Microprojection array immunization patch and method
First Claim
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1. A method for delivering an antigenic agent to a mammal, comprising:
- providing at least two transdermal delivery members, each of said members including a plurality of microprojections configured to pierce the stratum corneum and a reservoir containing a loading amount of said antigenic agent, said reservoir being adapted to be positioned in antigenic agent-transmitting relation with the mammal when the delivery member is applied to a skin site of the mammal;
delivering with a first of said at least two transdermal delivery members an induction amount of said antigenic agent;
delivering with a second of said at least two transdermal delivery members a first booster amount of said antigenic agent at least about 7 days after said delivery of said induction amount of said antigenic agent, said booster amount comprising up to about 50% by weight of said induction amount.
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Abstract
Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.
95 Citations
37 Claims
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1. A method for delivering an antigenic agent to a mammal, comprising:
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providing at least two transdermal delivery members, each of said members including a plurality of microprojections configured to pierce the stratum corneum and a reservoir containing a loading amount of said antigenic agent, said reservoir being adapted to be positioned in antigenic agent-transmitting relation with the mammal when the delivery member is applied to a skin site of the mammal;
delivering with a first of said at least two transdermal delivery members an induction amount of said antigenic agent;
delivering with a second of said at least two transdermal delivery members a first booster amount of said antigenic agent at least about 7 days after said delivery of said induction amount of said antigenic agent, said booster amount comprising up to about 50% by weight of said induction amount. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for vaccinating a mammal, comprising:
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providing at least two transdermal delivery members, each of said members comprising at least one microprojection configured to pierce the stratum corneum and a reservoir having a loading amount of an antigenic agent, said reservoir being positioned in antigenic agent-transmitting relation with said mammal;
delivering with a first of said at least two transdermal delivery members an induction amount of said antigenic agent;
delivering with a second of said at least two transdermal delivery members a booster amount of said antigenic agent at least about 7 days thereafter, said booster amount being up to about 50% by weight of said induction amount.
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37. A method for vaccinating a mammal, comprising:
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providing at least two transdermal delivery members, each of said members comprising at least one microprojection configured to pierce the stratum corneum and a reservoir having a loading amount of an antigenic agent, said reservoir being positioned in antigenic agent-transmitting relation with said mammal;
delivering with a first of said at least two transdermal delivery members an induction amount of said antigenic agent;
delivering with a second of said at least two transdermal delivery members a booster amount of said antigenic agent, said booster amount being up to about 50% by weight of said induction amount.
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Specification