Reduction of adverse inflammation
First Claim
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1. An implant or transplant which has been fabricated or modified to promote the isomerization of peroxynitrite anion to nitrate anion.
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Abstract
Reduction of the likelihood of adverse inflammatory reaction to an implant or a transplant is achieved through several mechanisms including the catalysis of isomerization of peroxynitrite by a hydrogel-bound peroxynitrite isomerization catalysts. A second mechanism controls acceptable and unacceptable dimensions of surface features of implants, such as vascular stents. A third mechanism fabricates implants from materials which are substantially free from alloys transition metals which produce ions of which catalyze cell killing radical formation.
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Citations
33 Claims
- 1. An implant or transplant which has been fabricated or modified to promote the isomerization of peroxynitrite anion to nitrate anion.
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6. A method for inhibiting inflammation associated with implantation or transplantation in a patient, said method comprising:
coating at least a portion of an implant device or transplantation structure with a material which catalyzes the isomerization of peroxynitrite anion to nitrate anion. - View Dependent Claims (7, 8, 9, 10)
- 11. A hydrogel for coating a medical implant or transplant, said hydrogel comprising a catalyst which promotes the isomerization of peroxynitrite anion to nitrate anion.
- 16. A medical implant having an exterior surface, said exterior surface having features with dimensions which are in a size range characteristic of pathogenic bacteria present at a surface density below a threshold value which promotes phagocytosis.
- 19. A method for fabricating a medical implant, said method comprising fabricating, treating, or coating at least an exterior surface of the implant so that said surface has features with dimensions which are in a size range characteristic of phagocytosis bacteria present at a surface density below a threshold value which promotes phagocytosis.
- 22. A medical implant having a surface which is substantially free from transition metals which form dissolved ions which catalyze the formation of cell killing radicals.
- 28. A method for fabricating a medical implant, said method comprising forming at least a surface portion of the implant from a material which is substantially free from transition metals which form dissolved ions which catalyze the formation of cell killing radicals.
Specification