Isolation and mobilization of stem cells expressing vegfr-1
First Claim
1. A method for isolation of mammalian stem cells comprising providing a population of cells;
- contacting the population of cells with a molecule that specifically binds VEGFR-1; and
isolating cells that bind the molecule that specifically binds VEGFR-1.
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Accused Products
Abstract
The present invention is directed to methods of isolating mammalian stem cells expressing the VEGF receptor VEGFR-1 and compositions thereof. The present invention is also directed to methods of using such isolated mammalian stem cells expressing VEGFR-1 to treat various conditions, which can involve inducing hematopoiesis, vasculogenesis and/or angiogenesis, myogenesis, and neurogenesis to treat the various condition. Finally, the present invention is directed to therapeutic methods using a molecule that binds and activates or stimulates VEGFR-1, for example, P1GF, to stimulate proliferation and/or differentiation and mobilization, i.e., motogenesis, of stem cells.
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Citations
24 Claims
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1. A method for isolation of mammalian stem cells comprising
providing a population of cells; -
contacting the population of cells with a molecule that specifically binds VEGFR-1; and
isolating cells that bind the molecule that specifically binds VEGFR-1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 18, 19, 20, 21, 22, 23, 24)
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- 14. A composition comprising a molecule that specifically binds VEGFR-1.
Specification