Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis

• US 20050027102A1
• Filed: 08/24/2004
• Published: 02/03/2005
• Est. Priority Date: 12/28/1992
• Status: Abandoned Application

• Current Assignee: Ian A. Nicholls, Klaus Mosbach, Olof Ramstrom
• Original Assignee: Ian A. Nicholls, Klaus Mosbach, Olof Ramstrom
• Inventors: Ramstrom, Olof, Nicholls, Ian A., Mosbach, Klaus
• Application Number:
  US10/923,727
• Publication Number:
  US 20050027102A1
• Time in Patent Office: Days
• US Class Current: 530/333
• CPC Class Codes: C07B 53/00 Asymmetric syntheses
• CPC Class Codes: C07K 1/042 characterised by the nature of the carrier
• CPC Class Codes: G01N 2600/00 Assays involving molecular imprinted polymers/polymers created around a molecular template

Abstract

Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regio-selective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.

Claims

1. Use of a molecularly imprinted polymer for stereoselective and/or regioselective synthesis, whereby the polymer acts as a stereoselectively and/or regioselectively interacting matrix, capable of interacting with at least one reactive species and directing a reaction to a reactive site of said species.

2-9. -9. (Canceled)

10. A method of using a molecularly imprinted polymer, comprising the steps of:

providing a molecularly imprinted polymer adapted for stereoselective and/or regioselective synthesis,

using said molecularly imprinted polymer as a stereoselective and/or regeioselectively binding matrix,

directing by said polymer of a stereoselective and/or regioselective reaction.

11. The method of claim 10, wherein said molecularly imprinted polymer is adapted to eliminate the need for at least one protecting group on a reactive species.

12. The method of claim 10, wherein said molecularly imprinted polymer is produced by imprinting a print molecule and monomers wherein the print molecule was covalently, but reversibly, bound to the monomers.

13. The method of claim 10, wherein the step of providing a molecularly imprinted polymer comprises selecting a molecularly imprinted polymer resulting from molecular imprinting by imprinting a print molecule and monomers wherein the initial interactions between the monomers and the print molecule were non-covalent.

14. A method for chemical synthesis, comprising the steps of:

providing a molecularly imprinted polymer which is imprinted for a reactive chemical species,

providing a solution having said chemical species, said solution being in contact with said molecularly imprinted polymer,

interacting said imprinted polymer with said chemical species,

reacting said chemical species with a reactant to produce a reaction product.

15. The method of claim 14, wherein said interaction is stereoselective and/or regioselective.

16. The method of claim 14, wherein said reaction product is a peptide or polypeptide.

17. The method of claim 14, wherein said reaction product is a disaccharide, oligosaccharide or polysaccharide.

18. The method of claim 14, wherein said reaction product is a dinucleotide, oligonucleotide or polynucleotide.