Optical in vivo analyte probe using embedded intradermal particles
First Claim
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1. A method for in vivo detection of an analyte in a subject, comprising the steps of:
- embedding sensitized particles within the skin of the subject, the sensitized particles having an adsorptive affinity for the analyte such that the analyte concentration at the surface of the sensitized particles is greater than the analyte concentration in the subject;
optically illuminating the sensitized particles with excitation radiation;
collecting and measuring optical radiation emitted by the sensitized particles; and
analyzing the emitted radiation to detect the analyte and/or quantify the concentration of the analyte in the subject.
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Abstract
A system and method of in vivo detection and quantification of one or more analytes. Small particles comprising a surface-active monolayer coating are embedded in the dermis. The surface-active monolayer acts to pre-concentrate the analyte by adsorbing the analyte from bulk solution. The concentrated analyte is more readily detected and quantified by one or more spectroscopic methods such as Raman spectroscopy
66 Citations
19 Claims
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1. A method for in vivo detection of an analyte in a subject, comprising the steps of:
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embedding sensitized particles within the skin of the subject, the sensitized particles having an adsorptive affinity for the analyte such that the analyte concentration at the surface of the sensitized particles is greater than the analyte concentration in the subject;
optically illuminating the sensitized particles with excitation radiation;
collecting and measuring optical radiation emitted by the sensitized particles; and
analyzing the emitted radiation to detect the analyte and/or quantify the concentration of the analyte in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An apparatus for in vivo determination of an analyte, comprising:
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a housing, the housing being attachable to a subject'"'"'s arm by a strap such that a face of the housing is approximately flush with a skin surface on the subject'"'"'s arm;
an optical path for conveying an incident beam of excitation light from an excitation source and for conveying collected scattered radiation to a detector;
the optical path comprising an angled mirror to direct the incident beam approximately perpendicular to the skin, and a focusing lens that focuses the incident beam on a tattoo spot in the skin and focuses the scattered radiation emitted from the tattoo spot. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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Specification